{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:22Z","timestamp":1787169682057,"version":"build-2736575974"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is well known that plasma creatinine concentration is affected by muscle mass, while some studies have suggested cystatin C is affected by body mass index (BMI). Our aim was to assess the effects of lean versus fat mass on cystatin C and creatinine derivative equations in estimating glomerular filtration rate (GFR) in healthy young men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three groups of participants were studied: those classified as normal (BMI 18-25 kg\/m 2 with body fat, 30%); muscular subjects (BMI .30 kg\/m 2 and body fat, 20%); and obese subjects (BMI .30 kg\/m 2 and body fat .30%). All underwent diethylenetriamine pentaacetic acid GFR, bio-electrical impedance and dual-energy X-ray absorptiometry body composition analysis, measurement of plasma cystatin C, creatinine and high-sensitivity C-reactive protein and completed a diet record.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cystatin C was highest in the obese group (0.77 mg\/L; 95% confidence intervals [CI] 0.69-0.77) and creatinine was highest in the muscular group (90.1 \u03bcmol\/L; 95% CI 84.3-96.0). On multivariate analysis, body fat and GFR (P = 0.003) were significant determinants of cystatin C; muscle mass and age affected creatinine significantly (P = 0.02). Using cystatin C equations, Le Bricon and Hoek showed significantly lower estimated GFR in the obese group but performed reasonably well within 50%, 30% and 20% of GFR. Creatinine equations showed significant underestimations of GFR for the muscular group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Body fat is a significant determinant of cystatin C while creatinine concentration is highly affected by muscle mass and age. Body composition plays an important role in the interpretation of renal function. Cystatin C equations are still accurate in predicting GFR in our healthy male group without chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2012.011241","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:24:28Z","timestamp":1352161468000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men"],"prefix":"10.1177","volume":"50","author":[{"given":"Janice S C","family":"Chew-Harris","sequence":"first","affiliation":[{"name":"Biochemistry Department, Medlab South Ltd, PO Box 25-091, Christchurch 8013;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Florkowski","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Unit, Canterbury Health Laboratories, Corner of Tuam Street and Hagley Avenue, PO Box 151;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"George","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Unit, Canterbury Health Laboratories, Corner of Tuam Street and Hagley Avenue, PO Box 151;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane L","family":"Elmslie","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Unit, Canterbury Health Laboratories, Corner of Tuam Street and Hagley Avenue, PO Box 151;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan H","family":"Endre","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christchurch School of Medicine, University of Otago, PO Box 4345, Christchurch 8014, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"bibr1-acb.2012.011241","unstructured":"National Kidney Foundation Guidelines. 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