{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:17:54Z","timestamp":1785597474997,"version":"3.56.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiofrequency ablation (RFA) is accepted as a minimally invasive treatment of renal cell carcinoma (RCC). However, RFA is not fully evaluated for treating RCC in patients with von Hippel Lindau (VHL) disease who cannot undergo surgery due to serious postoperative morbidity or mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the role of RFA of RCC in patients with VHL disease previously undergoing renal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Percutaneous RFA was performed for treating 14 RCCs in six patients who had undergone radical nephrectomy ( n = 3) or repeated nephron-sparing surgery ( n = 3). Treatment feasibility, complications, outcome, and the change of renal function were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>To completely ablate 14 RCCs, 23 ablations during 12 sessions were necessary. Of 14 RCCs, nine were in proximity (&lt;5 mm) to one or more following organs: bowel ( n = 4), ureteropelvic junction or pelvis ( n = 2), psoas muscle ( n = 2), vascular pedicle ( n = 1), and pancreas ( n = 1). Of 12 sessions, one major complication (pneumothorax) developed in one session (8%). No residual or recurrent tumors were identified at the ablation areas. However, new three solid tumors less than 1 cm in diameter developed during the follow-up period but ablation was withheld until these tumors had grown to more than 1 cm in size. The mean level of serum creatinine increased with 6.4% and the mean estimated glomerular filtration rate decreased by 12.8% after the last ablation compared to those before the initial ablation ( P &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite technical difficulties, percutaneous RFA is a promising treatment for VHL patients who cannot undergo surgery because of excellent treatment outcome and minimal change of renal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/ar.2011.100435","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T20:35:52Z","timestamp":1303936552000},"page":"680-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Percutaneous radiofrequency ablation of renal cell carcinomas in patients with von Hippel Lindau disease previously undergoing a radical nephrectomy or repeated nephron-sparing surgery"],"prefix":"10.1177","volume":"52","author":[{"given":"Sung Yoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Radiology and Center for Imaging Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Kwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Kyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Soo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Il","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong Chang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 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