{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:20:13Z","timestamp":1791404413423,"version":"4.3.3"},"reference-count":19,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bone scintigraphy is the standard procedure for the detection of bone metastases in breast cancer patients. FDG-PET\/CT has been reported to be a sensitive tool for tumor staging in different malignant diseases. However, its accuracy for the detection of bone metastases has not been compared to bone scintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare whole-body FDG-PET\/CT and bone scintigraphy for the detection of bone metastases on a lesion basis in breast cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Twenty-nine consecutive women (mean age 58 years, range 35-78 years) with histologically proven breast cancer were assessed with bone scintigraphy and whole-body FDG-PET\/CT. Twenty-one patients (72%) were suffering from primary breast cancer and eight patients (28%) were in aftercare with a history of advanced breast cancer. Both imaging procedures were assessed for bone metastases by a radiologist and a nuclear medicine physician. Concordant readings between bone scintigraphy and FDG-PET\/CT were taken as true. Discordant readings were verified with additional MRI imaging in all patients and follow-up studies in most patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 132 lesions were detected on bone scintigraphy, FDG-PET\/CT or both. According to the reference standard, 70\/132 lesions (53%) were bone metastases, 59\/132 lesions (45%) were benign, and three lesions (2%) remained unclear. The sensitivity of bone scintigraphy was 76% (53\/70) compared to 96% (67\/70) for FDG-PET\/CT. The specificity of bone scintigraphy and FDG-PET\/CT was 95% (56\/59) and 92% (54\/59), respectively. According to the reference standard bone metastases were present in eight out of the 29 patients (28%), whereas 20 patients (69%) were free of bone metastases. One (3%) patient had inconclusive readings on both modalities as well as on MRI and follow-up studies. Bone scintigraphy and FDG-PET\/CT correctly identified seven out of eight patients with bone metastases and 20 out of 20 patients free of metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>On a lesion-basis whole-body FDG-PET\/CT is more sensitive and equally specific for the detection of bone metastases compared with bone scintigraphy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/ar.2011.100507","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T20:49:33Z","timestamp":1317674973000},"page":"1009-1014","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Comparison of FDG-PET\/CT and bone scintigraphy for detection of bone metastases in breast cancer"],"prefix":"10.1177","volume":"52","author":[{"given":"Steffen","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Heusner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherko","family":"K\u00fcmmel","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"K\u00f6ninger","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Nagarajah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Boy","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forsting","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bockisch","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Antoch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stahl","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, 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