{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:42:39Z","timestamp":1784194959442,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the primary infection of pulmonary histoplasmosis, pulmonary lesions are commonly solitary and associated with hilar and\/or mediastinal nodal diseases, which spontaneously resolve, resulting in calcifications in individuals with normal cellular immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the lymphatic drainage to the mediastinum from each pulmonary segment and lobe using computed tomographic (CT) observations of a calcified primary complex pulmonary histoplasmosis and predict which patients with N2 disease that would benefit from surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We collected 585 CT studies of patients with primary complex histoplasmosis consisting of solitary calcified pulmonary lesions and calcified hilar and\/or mediastinal nodal disease. Using the N stage criteria of non-small cell lung cancer, we assessed the distribution of the involved hilar and mediastinal nodes depending on the pulmonary segment of the lesion, with a focus on skip involvement. We also assessed the correlation between the incidence of N1and skip N2 involvement and the mean number of involved mediastinal nodal stations in the non-skip N2 and skip N2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Skip involvement was common in the apical segment (9\/45, 20.0%), posterior segment (7\/31, 22.6%), and mediolbasal segment (13\/20, 65.0%) in the right lung, and in the apicoposterior segment (7\/55, 12.7%), lateral basal segment (6\/26, 23.1%), and posterobasal segment (16\/47, 34.0%) in the left lung. The incidence of skip involvement in each segment showed a significant inverse correlation with that of N1 involvement (r = \u20130.51, P &lt;0.05) in both lungs. The mean number of involved mediastinal nodal stations in the non-skip N2 and skip N2 groups in all segments of both lungs were 1.4 (434\/301) and 1.2 (93\/77), and the former was significantly greater than the latter ( P &lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data showed a predictable pattern of segmental and lobar lymphatic drainage to the mediastinum and suggested that skip involvement could represent the initial mediastinal node involvement via direct lymphatic drainage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/ar.2011.110467","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:30:25Z","timestamp":1327019425000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Pulmonary lymphatic drainage to the mediastinum based on computed tomographic observations of the primary complex of pulmonary histoplasmosis"],"prefix":"10.1177","volume":"53","author":[{"given":"Koji","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Radiology, Asahikawa Medical University and Hospital, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asahikawa Medical University and Hospital, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basim","family":"Nabaa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asahikawa Medical University and Hospital, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Junior","family":"van Beek","sequence":"additional","affiliation":[{"name":"Clinical Research Imaging Centre, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Stanford","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamio","family":"Aburano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asahikawa Medical University and Hospital, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"bibr-AR-11-0467C1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.06.016"},{"key":"bibr-AR-11-0467C2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.03.016"},{"key":"bibr-AR-11-0467C3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.061"},{"key":"bibr-AR-11-0467C4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.07.076"},{"key":"bibr-AR-11-0467C5","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00470-5"},{"key":"bibr-AR-11-0467C6","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2002.1321"},{"key":"bibr-AR-11-0467C7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.081"},{"key":"bibr-AR-11-0467C8","doi-asserted-by":"publisher","DOI":"10.1016\/S1556-0864(15)31526-4"},{"key":"bibr-AR-11-0467C9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.08.018"},{"key":"bibr-AR-11-0467C10","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930570302"},{"key":"bibr-AR-11-0467C11","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00314-7"},{"key":"bibr-AR-11-0467C12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70217-5"},{"key":"bibr-AR-11-0467C13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<864::AID-CNCR13>3.0.CO;2-Q"},{"key":"bibr-AR-11-0467C14","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116473"},{"key":"bibr-AR-11-0467C15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2003.10.012"},{"key":"bibr-AR-11-0467C16","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.12.067"},{"key":"bibr-AR-11-0467C17","first-page":"9","volume":"14","author":"Kawano 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