{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:46:38Z","timestamp":1777477598918,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnostic accuracy of FDG-PET\/CT for the detection of axillary lymph node metastases in breast cancer patients acquired 60 min after FDG administration is reported to be only moderate, especially due to low sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To test whether a delayed scan 90 min after FDG administration could enhance the diagnostic accuracy of FDG-PET\/CT for the detection of axillary lymph node metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Thirty-eight women suffering from primary breast cancer (mean age 52 years; range 25\u201378 years; standard deviation 14 years) underwent a pre-therapeutic dual-time-point FDG-PET\/CT scan. The maximum standardized uptake value (SUVmax) of axillary lymph nodes was measured at two different time points (time point T1: 60 min after FDG injection, time point T2: 90 min after FDG injection). SUVmax of axillary lymph nodes at T1 and T2 were assessed for statistical significance using a paired Wilcoxon-Test ( P &lt; 0.05). At T1 a qualitative analysis of the FDG-PET\/CT scan was performed to define physiologic and metastatic lymph nodes. At T2 an increase of the SUVmax of at least 3.75% over time was rated as indicating malignancy. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the accuracy of FDG-PET\/CT for the detection of axillary lymph node metastases was calculated at time points T1 and T2. Statistically significant differences were determined using Fisher's exact test ( P &lt; 0.05). Histopathology served as the standard of reference. A compartment based analysis was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Axillary lymph nodes had a mean SUVmax of 1.6 (range 0.6\u201310.8; SD 1.9) at T1 and a mean SUVmax of 1.8 (range 0.5\u201317.9; SD 3.5) at T2. This difference was statistically significant ( P = 0.047). The sensitivity, specificity, PPV, NPV, and accuracy of FDG-PET\/CT for the detection of axillary lymph node metastases was 81%, 100%, 100%, 88%, and 92% at T1, and 88%, 50%, 56%, 85%, and 66% at T2, respectively. This difference was not statistically significant ( P = 0.27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a slight increase of the FDG accumulation of axillary lymph nodes between 60 and 90 min after FDG administration. This increase did not translate into a statistical significant enhancement of the diagnostic accuracy of FDG-PET\/CT for the detection of axillary lymph nodes. Especially due to false-positive results a delayed FDG-PET\/CT scan 90 min after FDG administration is not able to enhance the diagnostic accuracy for the detection of lymph node metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/ar.2012.110420","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T23:56:09Z","timestamp":1335830169000},"page":"518-523","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic accuracy of dual-time-point 18F-FDG PET\/CT for the detection of axillary lymph node metastases in breast cancer patients"],"prefix":"10.1177","volume":"53","author":[{"given":"Steffen","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Hecktor","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Grabellus","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University at Duisburg-Essen, Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"P\u00f6ppel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Essen, University at Duisburg-Essen, Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Kimmig","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Forsting","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Antoch","sequence":"additional","affiliation":[{"name":"University of Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till A","family":"Heusner","sequence":"additional","affiliation":[{"name":"University of Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, 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