{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:42:08Z","timestamp":1790062928097,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the widespread use of PET\/CT, incidental hypermetabolic foci unrelated to the known malignancy have been described with increasing frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the frequency and clinical significance of incidental focal hypermetabolic uptake in the breast as detected by 18F-FDG PET\/CT, and to explore factors differentiating benign and malignant breast uptake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      From January 2005 to June 2010, a total of 51,971 whole-body FDG PET\/CT examinations were performed in our clinic. After excluding 7254 sets of PET\/CT data from patients known to have breast cancer, we retrospectively identified patients showing incidental focal hypermetabolic activity in the breast. Of 44,717 PET\/CT examinations conducted on 32,988 patients, we identified 131 patients with no previous known or suspected benign and malignant breast disease. The etiology, mean SUV\n                      <jats:sub>max<\/jats:sub>\n                      , and diameter of breast lesions were assessed. We also compared the presentation of the lesions on CT, mammography, and ultrasonography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 131 patients, 60 were histologically diagnosed with breast lesions, including 32 with malignant and 28 with benign lesions. An additional 11 patients were followed-up for more than 2 years and were clinically considered to have benign lesions. The remaining 60 patients who had neither histologic confirmation nor followed-up for more than 2 years were excluded. Therefore, 71 patients were finally included. The mean SUV\n                      <jats:sub>max<\/jats:sub>\n                      of 39 benign lesions and 32 malignant lesions were 2.02 \u00b1 1.52 and 3.71 \u00b1 3.83, respectively ( P = 0.0001). At a cut-off value of 2.3, the rate of malignancy and specificity of the mean SUVmax for differentiating benign and malignant breast lesions were 61.3%, 76.3, respectively. The CT data from PET\/CT revealed that the mean diameters of benign and malignant lesions were 1.19 \u00b1 0.97 cm and 2.26 \u00b1 1.96 cm, respectively ( P = 0.0009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Incidental focal 18F-FDG uptake in the breast as detected by PET\/CT was indicative of malignancy in 45% of patients. Both mean SUV\n                      <jats:sub>max<\/jats:sub>\n                      and diameter were greater for malignant than benign lesions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/ar.2012.120015","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T09:45:26Z","timestamp":1337247926000},"page":"530-535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Analysis of incidental focal hypermetabolic uptake in the breast as detected by 18F-FDG PET\/CT: clinical significance and differential diagnosis"],"prefix":"10.1177","volume":"53","author":[{"given":"Eun Young","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Hee","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Yeun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hwan","family":"Koh","sequence":"additional","affiliation":[{"name":"Center for Liver Cancer, National Cancer Center, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hyuk","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, 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