{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:47:38Z","timestamp":1777477658631,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"\n Background<\/jats:title>\n The use of pre-filled syringes for contrast media (CM) administration allows efficient and optimized workflow during radiologic diagnostic procedures, and reduces the risk of contamination, providing benefits for both patients and healthcare workers.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n \n To compare the efficiency and safety of ioversol (Optiray\n TM<\/jats:sup>\n ) bottles and pre-filled syringes in clinical practice.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n This was an observational, non-interventional, prospective, multicenter study conducted at 72 centers in Germany. Patients undergoing contrast-enhanced computed tomography (CT) examinations with ioversol were enrolled. The use of ioversol bottles and pre-filled syringes in the diagnostic procedure was recorded in terms of efficiency (residual volume, re-use of CM) and safety (adverse events [AEs]).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 10,836 patients were enrolled and included in this study. Ioversol bottles and syringes were used in 72% and 28% of cases, respectively. Analysis of the volume of CM in bottles before and after examinations, together with the volume used during the examination, suggested that in 22.5% of cases a new bottle was connected during the procedure. Further analysis revealed that in 80.2% of cases, the remaining volume of CM in the bottles could potentially be used for subsequent investigations, compared with <1% of cases for pre-filled syringes. For the total study population, AEs and serious AEs were reported in 30 (0.28%) and four (0.037%) patients, respectively, with no significant difference observed between ioversol bottles and syringes.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Administration of ioversol for contrast-enhanced CT examinations is associated with a low incidence of AEs and is generally safe and well tolerated. Ioversol pre-filled syringes were associated with lower residual volumes and less potential re-use compared with bottles.<\/jats:p>\n <\/jats:sec>","DOI":"10.1258\/ar.2012.120303","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T07:29:36Z","timestamp":1347694176000},"page":"914-920","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["An observational study to evaluate the efficiency and safety of ioversol pre-filled syringes compared with ioversol bottles in contrast-enhanced examinations"],"prefix":"10.1177","volume":"53","author":[{"given":"Thomas J","family":"Vogl","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Frankfurt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Wessling","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, University of Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Buerke","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, University of Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr-AR-12-0303C1","author":"Enterline DS","year":"2003","journal-title":"Imaging Economics"},{"key":"bibr-AR-12-0303C2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3189"},{"key":"bibr-AR-12-0303C3","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5924"},{"key":"bibr-AR-12-0303C4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3954"},{"key":"bibr-AR-12-0303C5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2003.06.004"},{"key":"bibr-AR-12-0303C6","first-page":"29","volume":"29","author":"Mongin-Bulewski C","year":"2006","journal-title":"Hospital Pharmacy Europe"},{"key":"bibr-AR-12-0303C7","first-page":"27","volume":"32","author":"Mongin-Bulewski C","year":"2007","journal-title":"Hospital Pharmacy Europe"},{"key":"bibr-AR-12-0303C8","first-page":"75","volume":"33","author":"Mongin-Bulewski C","year":"2007","journal-title":"Hospital Pharmacy Europe"},{"key":"bibr-AR-12-0303C9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-813520"},{"key":"bibr-AR-12-0303C11","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.1999.0607"},{"key":"bibr-AR-12-0303C12","doi-asserted-by":"publisher","DOI":"10.1086\/502176"},{"key":"bibr-AR-12-0303C13","doi-asserted-by":"publisher","DOI":"10.1086\/502313"},{"key":"bibr-AR-12-0303C14","doi-asserted-by":"publisher","DOI":"10.1086\/501557"},{"key":"bibr-AR-12-0303C15","doi-asserted-by":"publisher","DOI":"10.3201\/eid1402.060763"},{"key":"bibr-AR-12-0303C16","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32825b07b0"},{"key":"bibr-AR-12-0303C18","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199608000-00003"},{"key":"bibr-AR-12-0303C19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.09.018"},{"key":"bibr-AR-12-0303C20","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-15"},{"key":"bibr-AR-12-0303C21","doi-asserted-by":"publisher","DOI":"10.1016\/0720-048X(94)00593-2"},{"key":"bibr-AR-12-0303C22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1994.tb00148.x"},{"key":"bibr-AR-12-0303C23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1994.tb00147.x"},{"key":"bibr-AR-12-0303C24","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-63-751-532"},{"key":"bibr-AR-12-0303C25","volume-title":"Promoting safer use of injectable medicines. 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