{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:43:24Z","timestamp":1777873404212,"version":"3.51.4"},"reference-count":205,"publisher":"Frontiers Media SA","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n                    K\n                    <jats:sup>+<\/jats:sup>\n                    channels in coronary arterial smooth muscle cells (CASMC) determine the resting membrane potential ( E\n                    <jats:sub>m<\/jats:sub>\n                    ) and serve as targets of endogenous and therapeutic vasodilators. E\n                    <jats:sub>m<\/jats:sub>\n                    in CASMC is in the voltage range for activation of L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels; therefore, when K\n                    <jats:sup>+<\/jats:sup>\n                    channel activity changes, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx and arterial tone change. This is why both Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blockers and K\n                    <jats:sup>+<\/jats:sup>\n                    channel openers have such profound effects on coronary blood flow; the former directly inhibits Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx through L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels, while the latter indirectly inhibits Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx by hyperpolarizing E\n                    <jats:sub>m<\/jats:sub>\n                    and reducing Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel activity. K\n                    <jats:sup>+<\/jats:sup>\n                    channels in CASMC play important roles in vasodilation to endothelial, ischemic and metabolic stimuli. The purpose of this article is to review the types of K\n                    <jats:sup>+<\/jats:sup>\n                    channels expressed in CASMC, discuss the regulation of their activity by physiological mechanisms and examine impairments related to cardiovascular disease.\n                  <\/jats:p>","DOI":"10.1258\/ebm.2009.009201","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T12:59:36Z","timestamp":1275051576000},"page":"10-22","source":"Crossref","is-referenced-by-count":86,"title":["Role of potassium channels in coronary vasodilation"],"prefix":"10.3389","volume":"235","author":[{"given":"Gregory M","family":"Dick","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology and Center for Cardiovascular & Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnathan D","family":"Tune","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, 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