{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:43:41Z","timestamp":1777873421829,"version":"3.51.4"},"reference-count":45,"publisher":"Frontiers Media SA","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Soy diet ameliorates renal injury in the Han:SPRD- cy rat. The relative roles of protein, isoflavones and changes in polyunsaturated fatty acid (PUFA) status are not determined. We fed male Han:SPRD- cy heterozygotes casein (C), high isoflavone soy protein (HIS), alcohol-extracted low isoflavone soy protein (LIS) or mixed soy protein diet (MIS). LIS and MIS were associated with a small decrease in animal weight compared with HIS or C. Soy diets preserved normal renal function and reduced relative renal weight (10.9\u201314.6 g\/kg, cf. 23.6, P &lt; 0.001), scores for cystic change (0.168\u20130.239, cf. 0.386, P &lt; 0.05), fibrosis (0.013\u20130.015, cf. 0.032, P &lt; 0.05), tissue oxidized LDL content (0.012\u20130.021, cf. 0.048, P &lt; 0.05), inflammation (8.5\u201312.9, cf. 31.2, P &lt; 0.05) and epithelial cell proliferation (6.5\u201313.8, cf. 26.3, P &lt; 0.05). In post hoc testing, LIS produced a greater reduction in relative renal weight, cystic change and epithelial proliferation, whereas HIS produced a significantly greater reduction in oxidized-LDL. Soy diets were associated with increased hepatic content of 18C PUFA ( P &lt; 0.001). LIS and HIS diets were associated with a small increase in body fat content ( P &lt; 0.001). Alcohol-extracted soy protein retains its major protective effects in this model with subtle differences attributable to isoflavones.<\/jats:p>","DOI":"10.1258\/ebm.2010.010059","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T13:09:19Z","timestamp":1301922559000},"page":"1315-1320","source":"Crossref","is-referenced-by-count":13,"title":["Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet"],"prefix":"10.3389","volume":"235","author":[{"given":"Malcolm R","family":"Ogborn","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health"},{"name":"Department of Human Nutritional Sciences, University of Manitoba, Winnipeg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Nitschmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child 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