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In this study, we applied a 20 Hz vibration to ACL cells, which produced a 20% increase ( P &lt; 0.001) in cell activity and 17% increase ( P &lt; 0.001) in intracellular sulfated glycosaminoglycan levels. In the 20 Hz vibration-stimulated ACL cell group, eight up-regulated (100 \u223c 300%) protein spots were identified compared with the control group by proteomics analysis. Among these proteins, Annexin A2 and Prolyl 4 hydroxylase (PH4B) were shown to have a 71% and 16% higher expression, respectively, in the 20 Hz vibration-stimulated ACL cell group by Western blotting ( P &lt; 0.001). These results indicate that vibration produces a positive cellular environment, and Annexin A2 and prolyl 4 hydroxylase are expected to help ligament repair and ACL cell proliferation by controlling cell membrane and extracellular matrix formation.<\/jats:p>","DOI":"10.1258\/ebm.2011.010358","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T22:53:59Z","timestamp":1308696839000},"page":"783-789","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of vibration on the proteome expression of anterior cruciate ligament cells"],"prefix":"10.3389","volume":"236","author":[{"given":"Gi-Yeon","family":"Han","sequence":"first","affiliation":[{"name":"School of Life Sciences and Biotechnology, Korea University, 1-5, Anam Dong, Seongbuk-Gu, Seoul 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