{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:19:48Z","timestamp":1791533988574,"version":"4.3.4"},"reference-count":27,"publisher":"Frontiers Media SA","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Mast cell-mediated allergic reaction is involved in many diseases such as asthma and allergic rhinitis. Therefore, discovery of drugs for the prevention or treatment of allergic disease is an important topic in human health. In this study, we evaluated the effects of water extract of Elsholtzia ciliata (Thunb.) Hyland (Labiatae) (WEEC) on mast cell-mediated allergic inflammation and studied the possible mechanisms of action. WEEC inhibited compound 48\/80-induced systemic and immunoglobulin E-mediated local anaphylaxis, and serum histamine release in mice. WEEC reduced intracellular calcium levels and downstream histamine release from human mast cells (HMC-1) activated with phorbol 12-myristate 13-acetate and calcium ionophore A23187. In addition, WEEC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor- \u03b1, interleukin (IL)-1 \u03b2 and IL-6 in HMC-1. The inhibitory effect of WEEC on cytokine expression was nuclear factor (NF)- \u03baB and p38 mitogen-activated protein kinase (MAPK) dependent. Our results indicate that WEEC inhibits mast cell-mediated allergic inflammatory reactions by suppressing histamine release and proinflammatory cytokine expression, and involvement of calcium, NF- \u03baB and p38 MAPK in these effects.<\/jats:p>","DOI":"10.1258\/ebm.2011.011017","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T22:23:23Z","timestamp":1312237403000},"page":"1070-1077","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["<i>Elsholtzia ciliata<\/i>\n                    inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-\n                    <i>\u03ba<\/i>\n                    B"],"prefix":"10.3389","volume":"236","author":[{"given":"Hui-Hun","family":"Kim","sequence":"first","affiliation":[{"name":"CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Su","family":"Yoo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Woosuk University, Jeonju 565-701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Shik","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702-701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeg Kyu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Keimyung University, Daegu 704-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yong","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Woosuk University, Jeonju 565-701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"bibr-EBM-1101-RM-17C1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141025"},{"key":"bibr-EBM-1101-RM-17C2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1158"},{"key":"bibr-EBM-1101-RM-17C3","doi-asserted-by":"publisher","DOI":"10.1038\/nature07204"},{"key":"bibr-EBM-1101-RM-17C4","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj063"},{"key":"bibr-EBM-1101-RM-17C5","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.4049\/jimmunol.151.7.3853","volume":"151","author":"Bradding P","year":"1993","journal-title":"J Immunol"},{"key":"bibr-EBM-1101-RM-17C6","doi-asserted-by":"publisher","DOI":"10.1038\/339064a0"},{"key":"bibr-EBM-1101-RM-17C7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976835"},{"key":"bibr-EBM-1101-RM-17C8","doi-asserted-by":"publisher","DOI":"10.1021\/jf904091d"},{"key":"bibr-EBM-1101-RM-17C9","unstructured":"HanST. 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