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The focal loss of striatal cells, specifically medium-sized spiny neurons (MSN) in Huntington's disease (HD), makes transplantation a therapeutic option. Here, we review the progress made in generating striatal MSN phenotypes for transplantation in HD. We discuss the use of primary fetal tissue as a donor source in both preclinical and clinical studies and assess the options for renewable cell sources. We evaluate progress in directing the differentiation of renewable cells towards a striatal MSN phenotype for HD.<\/jats:p>","DOI":"10.1258\/ebm.2011.011359","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T20:22:46Z","timestamp":1333570966000},"page":"343-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Producing striatal phenotypes for transplantation in Huntington's disease"],"prefix":"10.3389","volume":"237","author":[{"given":"Sophie V","family":"Precious","sequence":"first","affiliation":[{"name":"Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E","family":"Rosser","sequence":"additional","affiliation":[{"name":"Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX"},{"name":"Departments of Neurology 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