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We report a case of early syphilitic hepatitis (ESH) in an immunocompetent patient referring multiple bisexual exposures, who presented at admission with jaundice, tiredness, an ulcerated genital lesion and an increase of liver aminotransferases. During his hospital stay, he developed a skin rash, and serology for syphilis was found positive. Our case report strengthens the need to take into consideration the diagnosis of ESH in all patients with unexplained liver enzyme increase and epidemiological data of unsafe sexual exposures. Indeed, an early recognition of the clinical manifestations of syphilis can lead to a prompt treatment, and allows the prevention of the transmission of this disease to other individuals. <\/jats:p>","DOI":"10.1258\/ijsa.2007.007037","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T01:32:22Z","timestamp":1202693542000},"page":"65-66","source":"Crossref","is-referenced-by-count":19,"title":["Early syphilitic hepatitis in an immunocompetent patient: really so uncommon?"],"prefix":"10.1177","volume":"19","author":[{"given":"P","family":"Noto","sequence":"first","affiliation":[{"name":"Clinical Department, 2nd Infectious Diseases Division, Via Portuense, 292 \u2013 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Del Nonno","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Institute for Infectious Diseases \u2018L Spallanzani\u2019, Via Portuense, 292 \u2013 00149 Rome, 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