{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T05:48:20Z","timestamp":1740980900022,"version":"3.38.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p> Gastrointestinal complications in AIDS patients with diarrhoea are common clinical manifestations, frequently diagnosed by colonoscopy as non-specific colitis. We retrospectively study colon biopsies diagnosed as chronic colitis associated with HIV (CCH). Biopsies were sorted as patients with AIDS (serum CD4 &lt;200 cell\/mm<jats:sup>3<\/jats:sup>) but without any clear infectious process (n = 12) and patients without HIV infection (n = 24). There are low numbers of CD4+ T lymphocytes in lamina propria of AIDS patients, but CD8+ T populations in this area appear to be similar in all studied groups, regardless of HIV infection or laboratory evidence of a specific agent. We found the clear evidence of CD8+ T cells infiltration in colonic mucosa in HIV patients with microscopic colitis. An imbalance of lymphocyte subpopulations in the colon, both in the lamina propria and epithelium, could result in an intraepithelial CD8 infiltration, involved in the pathogenesis of CCH in AIDS patients. <\/jats:p>","DOI":"10.1258\/ijsa.2007.007282","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:12:55Z","timestamp":1217265175000},"page":"524-528","source":"Crossref","is-referenced-by-count":4,"title":["Chronic colitis associated with HIV infection can be related to intraepithelial infiltration of the colon by CD8+ T lymphocytes"],"prefix":"10.1177","volume":"19","author":[{"given":"Elaine Raniero","family":"Fernandes","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio da Disciplina de Patologia de Mol\u00e9stias Transmiss\u00edveis, Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Dr Arnaldo, 455 Cerqueira C\u00e9sar 01246-903, S\u00e3o Paulo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Pagliari","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio da Disciplina de Patologia de Mol\u00e9stias Transmiss\u00edveis, Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Dr Arnaldo, 455 Cerqueira C\u00e9sar 01246-903, S\u00e3o Paulo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Francisco","family":"Tuon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heitor Franco","family":"De Andrade","sequence":"additional","affiliation":[{"name":"Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Averbach","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio da Disciplina de Patologia de Mol\u00e9stias Transmiss\u00edveis, Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Dr Arnaldo, 455 Cerqueira C\u00e9sar 01246-903, S\u00e3o Paulo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Irma Seixas","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio da Disciplina de Patologia de Mol\u00e9stias Transmiss\u00edveis, Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Dr Arnaldo, 455 Cerqueira C\u00e9sar 01246-903, S\u00e3o Paulo;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"bibr1-ijsa.2007.007282","first-page":"18","volume":"22","author":"Thorn K","year":"2006","journal-title":"Curr Opin Gastroenterol"},{"key":"bibr2-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000015282.24774.36"},{"key":"bibr3-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088747"},{"key":"bibr4-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-1042-THOCCB"},{"key":"bibr5-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1992.tb121507.x"},{"key":"bibr6-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1097\/01.mog.0000174219.07957.36"},{"key":"bibr7-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000175115.63165.6b"},{"key":"bibr8-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.45.1.105"},{"key":"bibr9-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200004000-00008"},{"key":"bibr10-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200108000-00006"},{"key":"bibr11-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2006.0121"},{"key":"bibr12-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01081.x"},{"key":"bibr13-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01454-X"},{"key":"bibr14-ijsa.2007.007282","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4909"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2007.007282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/ijsa.2007.007282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2007.007282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T18:22:15Z","timestamp":1740939735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/ijsa.2007.007282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1258\/ijsa.2007.007282"],"URL":"https:\/\/doi.org\/10.1258\/ijsa.2007.007282","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}