{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T05:56:57Z","timestamp":1740981417206,"version":"3.38.0"},"reference-count":8,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p> Health-care workers may be exposed to bullous fluid while caring for bullous skin diseases in HIV-infected patients. Given that bullous fluid is a filtrate of plasma, it may be assumed that HIV viral load (VL) in bullous fluid is close to plasma VL. This was documented in a patient who had discontinued antiretroviral therapy because of nevirapine-associated toxic epidermal necrolysis, but no data are available in patients receiving antiretrovirals. An HIV-infected woman was admitted for leg cellulitis with a large bullous lesion. Her plasma HIV RNA had been undetectable for two years under the combination of efavirenz and boosted lopinavir. Bullous fluid analysis revealed undetectable HIV-1 RNA, while efavirenz and lopinavir concentrations were 1.4 and 3.4 \u03bcg\/mL, respectively. The ratio of bullous fluid\/plasma concentrations was 0.74 for efavirenz and 0.26 for lopinavir. These data may help us evaluate the need for antiretroviral prophylaxis after occupational exposure to bullous lesions fluid. <\/jats:p>","DOI":"10.1258\/ijsa.2007.007327","type":"journal-article","created":{"date-parts":[[2008,6,30]],"date-time":"2008-06-30T18:21:47Z","timestamp":1214850107000},"page":"357-358","source":"Crossref","is-referenced-by-count":0,"title":["Undetectable HIV-1 Viral Load in the Fluid of Bullous Skin Lesion in a Patient Receiving Highly Active Antiretroviral Therapy"],"prefix":"10.1177","volume":"19","author":[{"given":"Pierre","family":"Tattevin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Maillard","sequence":"additional","affiliation":[{"name":"Department of Virology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Tribut","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pontchaillou University Hospital, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Sa\u00edkali","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric","family":"Arvieux","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Michelet","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"bibr1-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306103282304"},{"key":"bibr2-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)91384-3"},{"key":"bibr3-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000162230.83188.32"},{"key":"bibr4-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp020892"},{"key":"bibr5-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.11.011"},{"key":"bibr6-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.015"},{"key":"bibr7-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.7748\/ns.7.48.25.s47"},{"key":"bibr8-ijsa.2007.007327","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363080-00004"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2007.007327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/ijsa.2007.007327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2007.007327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:06:46Z","timestamp":1740960406000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/ijsa.2007.007327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1258\/ijsa.2007.007327"],"URL":"https:\/\/doi.org\/10.1258\/ijsa.2007.007327","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}