{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:06:03Z","timestamp":1773381963882,"version":"3.50.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p> A retrospective case-notes audit of 359 HIV-1-infected adult patients with first-episode laboratory-confirmed Pneumocystis jirovecii pneumonia treated with co-trimoxazole (from 1987 adjuvant steroids were used if PaO<jats:sub>2<\/jats:sub> &lt;9.3 kPa) showed that only 230\/359 (64%) patients completed treatment; 104 (29%) patients had treatment-limiting toxicity; rash occurred in 4\/60 (6.7%) patients in 1985\u20131988 and in 15\/47 (31.9%) in 2005\u20132008. Twenty-five patients (7%) failed co-trimoxazole treatment. Overall mortality was 13.6% (49\/359); mortality among patients who failed co-trimoxazole treatment was 48% (12\/25) and by contrast mortality was 4.8% (5\/104) among patients with treatment-limiting toxicity. <\/jats:p>","DOI":"10.1258\/ijsa.2009.008470","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T17:29:44Z","timestamp":1251307784000},"page":"652-653","source":"Crossref","is-referenced-by-count":15,"title":["Outcome from treatment of <i>Pneumocystis jirovecii<\/i> pneumonia with co-trimoxazole"],"prefix":"10.1177","volume":"20","author":[{"given":"M","family":"Fisk","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, Camden Provider Services PCT, Mortimer Market Centre, London WC1E 6JB"},{"name":"T8, University College London Hospitals, London NW1 8BU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E K","family":"Sage","sequence":"additional","affiliation":[{"name":"T8, University College London Hospitals, London NW1 8BU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S G","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Camden Provider Services PCT, Mortimer Market Centre, London WC1E 6JB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Cartledge","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Camden Provider Services PCT, Mortimer Market Centre, London WC1E 6JB"},{"name":"T8, University College London Hospitals, London NW1 8BU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Miller","sequence":"additional","affiliation":[{"name":"T8, University College London Hospitals, London NW1 8BU"},{"name":"Department of Infection and Population Health, University College London Medical School, University College London, London W1E 6JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"bibr-IJSA-08-470C1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-1-37"},{"key":"bibr-IJSA-08-470C2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-4-280"},{"key":"bibr-IJSA-08-470C3","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199203000-00007"},{"key":"bibr-IJSA-08-470C4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90627-X"},{"key":"bibr-IJSA-08-470C5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.5.1295"},{"key":"bibr-IJSA-08-470C6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-4-495"},{"key":"bibr-IJSA-08-470C7","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31816de84d"},{"key":"bibr-IJSA-08-470C8","doi-asserted-by":"publisher","DOI":"10.1086\/526778"},{"key":"bibr-IJSA-08-470C9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.40110.x"},{"key":"bibr-IJSA-08-470C10","unstructured":"National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the HIV Medicine Association of the Infectious Diseases Society of America (HIVMA\/IDSA). Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents (2008). http:\/\/aidsinfo.nih.gov\/contentfiles\/Adult_OI.pdf (last accessed 18 November 2008)"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2009.008470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/ijsa.2009.008470","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2009.008470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T13:08:26Z","timestamp":1741007306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/ijsa.2009.008470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1258\/ijsa.2009.008470"],"URL":"https:\/\/doi.org\/10.1258\/ijsa.2009.008470","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}