{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:48:30Z","timestamp":1791215310518,"version":"4.1.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> We report the case of an HIV-positive man who presented with pyrexia of unknown origin. Histological specimens from an inguinal lymph node and liver biopsy gave a diagnosis of Epstein Barr virus (EBV)-positive Hodgkin's lymphoma and haemophagocytic lymphohistiocytosis (HLH), respectively. HLH is a condition characterized by proliferation of activated macrophages that phagocytose leukocytes, erythrocytes and platelets. Clinical features include splenomegaly, fever and pancytopenia, all of which have a wide differential diagnosis in HIV-positive patients. HLH can be caused by infections, malignancy, drugs or autoimmune conditions. There have been a number of reports of HLH in HIV-positive patients, and it can be seen at all stages of HIV infection. HIV, lymphomas, EBV infection and haemophagocytic syndrome have a complicated pathophysiology. Unfortunately, HLH in this setting has a particularly aggressive course, often with a poor outcome. This case highlights the need for awareness of the syndrome to ensure prompt diagnosis and instigation of appropriate treatment. <\/jats:p>","DOI":"10.1258\/ijsa.2010.009547","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T21:56:33Z","timestamp":1288043793000},"page":"601-603","source":"Crossref","is-referenced-by-count":12,"title":["Haemophagocytic lymphohistiocytosis complicating Hodgkin's lymphoma in an HIV-positive individual"],"prefix":"10.1177","volume":"21","author":[{"given":"S J","family":"Flew","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, Whittall Street Clinic, Birmingham B4 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K W","family":"Radcliffe","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Whittall Street Clinic, Birmingham B4 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"bibr-IJSA-09-547C1","doi-asserted-by":"publisher","DOI":"10.1089\/108729103322494285"},{"key":"bibr-IJSA-09-547C2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0606.000608"},{"key":"bibr-IJSA-09-547C3","unstructured":"SchwartzRA. Lymphohistiocytosis (haemophagocytic lymphohistiocytosis). eMedicine. 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