{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:46:47Z","timestamp":1741067207880,"version":"3.38.0"},"reference-count":7,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p> Adverse drug reactions occur at a greater frequency in HIV-infected individuals. A 38-year-old Eritrean man was treated with outpatient co-trimoxazole for confirmed Pneumocystis jirovecii pneumonia, but was switched to clindamycin and primaquine due to nausea and vomiting. Following development of methaemaglobinaemia, he was recommenced on prophylactic co-trimoxazole. He was later found moribund with features resembling septic shock and required invasive respiratory support. The diagnosis of a rare, but severe reaction to co-trimoxazole did not become apparent until he was rechallenged with prophylactic co-trimoxazole after recovery from his initial severe reaction. In an era of polypharmacy and an increasing availability of novel drugs, this case is a timely reminder to clinicians of the ongoing need for pharmacovigilance, especially in HIV-infected individuals who may have unusual presentations of an adverse drug reaction. <\/jats:p>","DOI":"10.1258\/ijsa.2010.010079","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T23:10:34Z","timestamp":1284765034000},"page":"521-523","source":"Crossref","is-referenced-by-count":5,"title":["Severe septic-shock like reaction to co-trimoxazole in an HIV-positive man"],"prefix":"10.1177","volume":"21","author":[{"given":"A","family":"Scourfield","sequence":"first","affiliation":[{"name":"Department of HIV Medicine, Chelsea and Westminster Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L K K","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Imperial College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of HIV Medicine, Chelsea and Westminster Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"bibr-IJSA-10-079C1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421907"},{"key":"bibr-IJSA-10-079C2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32825ea68a"},{"key":"bibr-IJSA-10-079C3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.4.1003"},{"key":"bibr-IJSA-10-079C4","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200194030-00017"},{"key":"bibr-IJSA-10-079C5","first-page":"23","volume":"97","author":"Ryan C","year":"1998","journal-title":"WMJ"},{"key":"bibr-IJSA-10-079C6","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.5.1034"},{"key":"bibr-IJSA-10-079C7","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91046-W"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2010.010079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/ijsa.2010.010079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2010.010079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T16:42:21Z","timestamp":1741020141000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/ijsa.2010.010079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1258\/ijsa.2010.010079"],"URL":"https:\/\/doi.org\/10.1258\/ijsa.2010.010079","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}