{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:45:15Z","timestamp":1760820315064,"version":"3.38.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p> Cryptococcal meningitis (CM) is a major cause of death among HIV-infected persons in sub-Saharan Africa. We conducted a study to describe the long-term outcomes during the pre-antiretroviral post-ART therapy period. Enrolled cases were those detected through population-based surveillance in Gauteng Province, South Africa, and diagnosed during March\u2013November 2002 and July\u2013September 2003 from eight large hospitals representing academic, provincial and rural settings. Of 1089 case-patients diagnosed with CM, 721 (70%) survived to discharge. Among the 256 with follow-up information, 154 (60%) were established to have died, 44% of whom died as outpatients. Overall, the 14- and 90-day survival post-diagnosis was 68% and 41%, respectively. On Cox proportional hazards multivariable analysis, severe disease was associated with shorter survival time; having received any antifungal treatment for the cryptococcal episode was associated with increased survival time at follow-up. Although most patients in this cohort survived the initial hospitalization, only 41% were still alive three months after diagnosis, with nearly half of deaths occurring outside a hospital. These data are an important baseline from which to measure effectiveness of public health management of CM in South Africa. <\/jats:p>","DOI":"10.1258\/ijsa.2010.010235","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T16:13:10Z","timestamp":1303488790000},"page":"199-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Long-term follow-up and survival of antiretroviral-na\u00efve patients with cryptococcal meningitis in the pre-antiretroviral therapy era, Gauteng Province, South Africa"],"prefix":"10.1177","volume":"22","author":[{"given":"B J","family":"Park","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Shetty","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ahlquist","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Miller","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Motsi","sequence":"additional","affiliation":[{"name":"Mycology Reference Unit, National Institute for Communicable Diseases, a division of the National Health Laboratory Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Reproductive Health and HIV Research Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Govender","sequence":"additional","affiliation":[{"name":"Mycology Reference Unit, National Institute for Communicable Diseases, a division of the National Health Laboratory Service"},{"name":"Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"bibr-IJSA-10-235C1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"bibr-IJSA-10-235C2","unstructured":"UNAIDS. 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