{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:16:59Z","timestamp":1790295419121,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p> The aims of the study were to assess whether Treponema pallidum-specific IgM may provide a useful marker of infectious syphilis in human immunodeficiency virus (HIV)-infected patients, and to compare the performance of a prototype IgM-rapid point-of-care test (PoCT) with a standard IgM-enzyme immunoassay (EIA). Twenty samples from HIV-infected patients with untreated syphilis ( n = 4 primary syphilis, n = 11 secondary and n = 5 early latent) and 51 follow-up samples at three, six or 12 months after treatment were tested for the presence of IgM with the Mercia-EIA (Microgen Bioproducts Ltd, Camberley, UK) and a prototype PoCT (Select Vaccines Ltd, Melbourne, Australia). Although sample numbers were small, IgM detection by EIA appears to be a reliable marker for untreated syphilis in HIV-infected patients with primary (4\/4 IgM-positive) or secondary syphilis (10\/11 IgM-positive, 1\/11 equivocal). After treatment, IgM was no longer detected after three months in the majority of patients (87%) and was either negative or equivocal in all patients after six and 12 months. The overall sensitivity of the IgM-PoCT was 82% and varied with clinical stage, being highest in secondary (10\/10 EIA positives) but lower in primary (2\/4 EIA positives) and early latent syphilis (2\/3 EIA positives). Overall specificity was 95%. Rapid detection of IgM would enable clinicians to distinguish between past-treated and infectious syphilis and allow for diagnosis and treatment in a single visit. <\/jats:p>","DOI":"10.1258\/ijsa.2010.010237","type":"journal-article","created":{"date-parts":[[2010,12,27]],"date-time":"2010-12-27T19:28:06Z","timestamp":1293478086000},"page":"758-764","source":"Crossref","is-referenced-by-count":5,"title":["Preliminary assessment of <i>Treponema pallidum<\/i>-specific IgM antibody detection and a new rapid point-of-care assay for the diagnosis of syphilis in human immunodeficiency virus-1-infected patients"],"prefix":"10.1177","volume":"21","author":[{"given":"J","family":"Rotty","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Alfred Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Anderson","sequence":"additional","affiliation":[{"name":"Macfarlane Burnet Institute for Medical Research and Public Health"},{"name":"Select Vaccines Ltd, Melbourne"},{"name":"Department of Microbiology, Monash University"},{"name":"Department of Immunology, Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Garcia","sequence":"additional","affiliation":[{"name":"Macfarlane Burnet Institute for Medical Research and Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Diaz","sequence":"additional","affiliation":[{"name":"Macfarlane Burnet Institute for Medical Research and Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Van de Waarsenburg","sequence":"additional","affiliation":[{"name":"Macfarlane Burnet Institute for Medical Research and Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Howard","sequence":"additional","affiliation":[{"name":"Macfarlane Burnet Institute for Medical Research and Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dennison","sequence":"additional","affiliation":[{"name":"Microbiology Unit, The Alfred Pathology Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Lewin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Alfred Hospital"},{"name":"Macfarlane Burnet Institute for Medical Research and Public Health"},{"name":"Department of Medicine, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Elliott","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Alfred Hospital"},{"name":"Department of Medicine, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hoy","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Alfred Hospital"},{"name":"Department of Medicine, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"bibr-IJSA-10-237C1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2008.04.002"},{"key":"bibr-IJSA-10-237C2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.1.250-253.2003"},{"key":"bibr-IJSA-10-237C3","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198610000-00002"},{"key":"bibr-IJSA-10-237C4","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008104"},{"key":"bibr-IJSA-10-237C5","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008103"},{"key":"bibr-IJSA-10-237C6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2008.00164.x"},{"key":"bibr-IJSA-10-237C7","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31815e4011"},{"key":"bibr-IJSA-10-237C8","unstructured":"World Health Organization. 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