{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:30:10Z","timestamp":1784799010225,"version":"3.55.0"},"reference-count":98,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> After years of declining incidence in many developed countries, syphilis infection has re-emerged as a major public health problem in the past decade. The secondary stage of syphilis epitomizes the capacity of the infection to present in myriad ways. The skin, lymph glands and mucosal membranes are the most commonly affected tissues. <\/jats:p>","DOI":"10.1258\/ijsa.2010.010243","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T21:56:33Z","timestamp":1288043793000},"page":"537-545","source":"Crossref","is-referenced-by-count":41,"title":["Secondary syphilis: the classical triad of skin rash, mucosal ulceration and lymphadenopathy"],"prefix":"10.1177","volume":"21","author":[{"given":"C","family":"Mullooly","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, North Manchester General Hospital, Crumpsall, Manchester M8 5RB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S P","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, North Manchester General Hospital, Crumpsall, Manchester M8 5RB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"bibr-IJSA-10-243C1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2007.007258"},{"key":"bibr-IJSA-10-243C2","doi-asserted-by":"publisher","DOI":"10.1086\/511426"},{"key":"bibr-IJSA-10-243C3","doi-asserted-by":"publisher","DOI":"10.1086\/513427"},{"key":"bibr-IJSA-10-243C4","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000149848.03733.c1"},{"key":"bibr-IJSA-10-243C5","unstructured":"Health Protection Agency. Health Protection Report: HIV and Sexually Transmitted Infections. 2008;44:31 Oct"},{"key":"bibr-IJSA-10-243C6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400030071013"},{"key":"bibr-IJSA-10-243C7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-2-199407150-00003"},{"key":"bibr-IJSA-10-243C8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-6-846"},{"key":"bibr-IJSA-10-243C9","first-page":"197","volume-title":"Pathogenic Treponema: Molecular and Cellular Biology","author":"Radolf JD","year":"2006"},{"key":"bibr-IJSA-10-243C10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.6.2051"},{"key":"bibr-IJSA-10-243C11","first-page":"224","volume-title":"Diagnostic Molecular Microbiology. Principles and Applications","author":"Radolf JD","year":"1993"},{"key":"bibr-IJSA-10-243C12","first-page":"285","volume-title":"Pathogenic Treponema: Molecular and Cellular Biology","author":"Radolf JD","year":"2006"},{"key":"bibr-IJSA-10-243C13","volume-title":"Modern Clinical Syphilology","author":"Stokes JH","year":"1944","edition":"3"},{"key":"bibr-IJSA-10-243C14","first-page":"1","volume":"65","author":"Mindel A","year":"1989","journal-title":"Genitourin Med"},{"key":"bibr-IJSA-10-243C15","volume-title":"Essentials of Syphilology","author":"Kampmeier RH","year":"1943","edition":"3"},{"key":"bibr-IJSA-10-243C16","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200103000-00007"},{"key":"bibr-IJSA-10-243C17","first-page":"3","volume":"35","author":"Gjestland T","year":"1955","journal-title":"Acta Derm Venereol"},{"key":"bibr-IJSA-10-243C18","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.9.3845-3852.1996"},{"key":"bibr-IJSA-10-243C19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.11.5455"},{"key":"bibr-IJSA-10-243C20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.47.33419"},{"key":"bibr-IJSA-10-243C21","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.4049\/jimmunol.160.11.5485","volume":"160","author":"Wooten RM","year":"1998","journal-title":"J Immunol"},{"key":"bibr-IJSA-10-243C22","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.732"},{"key":"bibr-IJSA-10-243C23","doi-asserted-by":"publisher","DOI":"10.1038\/nm732"},{"key":"bibr-IJSA-10-243C24","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00202-2"},{"key":"bibr-IJSA-10-243C25","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01638-6"},{"key":"bibr-IJSA-10-243C26","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.3.1048-1050.1996"},{"key":"bibr-IJSA-10-243C27","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.2.491"},{"key":"bibr-IJSA-10-243C28","first-page":"24","volume-title":"Principles and Practice of Infectious Diseases","author":"Tramont EC","year":"2000","edition":"5"},{"key":"bibr-IJSA-10-243C29","first-page":"141","volume-title":"Advances in Host Defense Mechanisms: Sexually Transmitted Diseases","author":"Lukehart SA","year":"1992"},{"key":"bibr-IJSA-10-243C30","first-page":"1","volume-title":"Immunology of Sexually Transmitted Diseases","author":"Norris SJ","year":"1998"},{"key":"bibr-IJSA-10-243C31","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199910000-00005"},{"key":"bibr-IJSA-10-243C32","first-page":"399","volume":"10","author":"Jordaan HF","year":"1988","journal-title":"Am J Dermatopathol"},{"key":"bibr-IJSA-10-243C33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2340\/0001555561371380","volume":"61","author":"Bjerke JR","year":"1981","journal-title":"Acta Dermatologica Venereologica"},{"key":"bibr-IJSA-10-243C34","doi-asserted-by":"publisher","DOI":"10.1177\/095646249100200411"},{"key":"bibr-IJSA-10-243C35","doi-asserted-by":"publisher","DOI":"10.1086\/511822"},{"key":"bibr-IJSA-10-243C36","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1681"},{"key":"bibr-IJSA-10-243C37","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80694-7"},{"key":"bibr-IJSA-10-243C38","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2001.0674"},{"key":"bibr-IJSA-10-243C39","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.205-216.2005"},{"key":"bibr-IJSA-10-243C40","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198010000-00002"},{"key":"bibr-IJSA-10-243C41","first-page":"180","volume-title":"Pathologie und Therapie der Syphilis","author":"Kaposi M","year":"1891"},{"key":"bibr-IJSA-10-243C42","doi-asserted-by":"publisher","DOI":"10.1159\/000245600"},{"key":"bibr-IJSA-10-243C43","first-page":"195","volume":"53","author":"Lejman K","year":"1977","journal-title":"Br J Vener Dis"},{"key":"bibr-IJSA-10-243C44","unstructured":"MusherD. In: HolmesKK, MardhPA, SparlingPF, eds. Sexually Transmitted Diseases. 3rd edn. New York, NY: McGraw-Hill Co. 1999:481"},{"key":"bibr-IJSA-10-243C45","first-page":"176","volume":"72","author":"Sch\u00f6fer H","year":"1996","journal-title":"Genitourin Med"},{"key":"bibr-IJSA-10-243C46","first-page":"355","volume":"52","author":"Amon RB","year":"1976","journal-title":"Br J Ven Dis"},{"key":"bibr-IJSA-10-243C47","first-page":"570","volume":"20","author":"Pangalis GA","year":"1993","journal-title":"Semin Oncol"},{"key":"bibr-IJSA-10-243C48","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.023085"},{"key":"bibr-IJSA-10-243C49","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1188114"},{"key":"bibr-IJSA-10-243C50","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.1"},{"key":"bibr-IJSA-10-243C51","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.34.1.49-54.1996"},{"key":"bibr-IJSA-10-243C52","doi-asserted-by":"publisher","DOI":"10.1136\/sti.79.6.479"},{"key":"bibr-IJSA-10-243C53","first-page":"43","volume":"3","author":"Rodionova EN","year":"2003","journal-title":"Zh Mikrobiol Epidemiol Immunobiol"},{"key":"bibr-IJSA-10-243C54","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.034314"},{"key":"bibr-IJSA-10-243C55","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.022467"},{"key":"bibr-IJSA-10-243C56","first-page":"158","volume":"3","author":"Egglestone SI","year":"2000","journal-title":"Commun Dis Public Health"},{"key":"bibr-IJSA-10-243C57","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000092571.52330.13"},{"key":"bibr-IJSA-10-243C58","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000121204.58881.60"},{"key":"bibr-IJSA-10-243C59","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70153-9"},{"key":"bibr-IJSA-10-243C60","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-492"},{"key":"bibr-IJSA-10-243C61","unstructured":"LeverWF. Histopathology of the Skin. 4th edn. Philadelphia: Lippincott, 1967:322"},{"key":"bibr-IJSA-10-243C62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb06476.x"},{"key":"bibr-IJSA-10-243C63","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00236.x"},{"key":"bibr-IJSA-10-243C64","first-page":"135","volume":"103","author":"Beckett J","year":"1979","journal-title":"Arch Pathol Lab Med"},{"key":"bibr-IJSA-10-243C65","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00029.x"},{"key":"bibr-IJSA-10-243C66","doi-asserted-by":"publisher","DOI":"10.1086\/498899"},{"key":"bibr-IJSA-10-243C67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040216"},{"key":"bibr-IJSA-10-243C68","doi-asserted-by":"publisher","DOI":"10.1086\/600878"},{"key":"bibr-IJSA-10-243C69","doi-asserted-by":"publisher","DOI":"10.1258\/095646206778113096"},{"key":"bibr-IJSA-10-243C70","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009233"},{"key":"bibr-IJSA-10-243C71","doi-asserted-by":"publisher","DOI":"10.1086\/644737"},{"key":"bibr-IJSA-10-243C72","doi-asserted-by":"publisher","DOI":"10.1086\/381227"},{"key":"bibr-IJSA-10-243C73","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000230481.28936.e5"},{"key":"bibr-IJSA-10-243C74","first-page":"9","volume":"11","author":"Cousins DE","year":"2010","journal-title":"HIV Medicine"},{"key":"bibr-IJSA-10-243C75","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008279"},{"key":"bibr-IJSA-10-243C76","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008510"},{"key":"bibr-IJSA-10-243C77","first-page":"1","volume":"55","author":"Workowski KA","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"bibr-IJSA-10-243C78","first-page":"721","volume":"45","author":"Jarisch A","year":"1895","journal-title":"Wiener Medizinische Wochenschrift"},{"key":"bibr-IJSA-10-243C79","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1139096"},{"key":"bibr-IJSA-10-243C80","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-12-1005"},{"key":"bibr-IJSA-10-243C81","doi-asserted-by":"publisher","DOI":"10.1042\/cs0430343"},{"key":"bibr-IJSA-10-243C82","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197607222950409"},{"key":"bibr-IJSA-10-243C83","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.5.1207"},{"key":"bibr-IJSA-10-243C84","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.suppl_1.25"},{"key":"bibr-IJSA-10-243C85","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03350330094030"},{"key":"bibr-IJSA-10-243C86","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008104"},{"key":"bibr-IJSA-10-243C87","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03200180015003"},{"key":"bibr-IJSA-10-243C88","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70063-7"},{"key":"bibr-IJSA-10-243C89","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198007000-00003"},{"key":"bibr-IJSA-10-243C90","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707313370504"},{"key":"bibr-IJSA-10-243C91","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.021402"},{"key":"bibr-IJSA-10-243C92","doi-asserted-by":"publisher","DOI":"10.1086\/644618"},{"key":"bibr-IJSA-10-243C93","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2003.007179"},{"key":"bibr-IJSA-10-243C94","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009155"},{"key":"bibr-IJSA-10-243C95","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008173"},{"key":"bibr-IJSA-10-243C96","first-page":"217","volume":"59","author":"Schober PC","year":"1983","journal-title":"Br J Ven Dis"},{"key":"bibr-IJSA-10-243C97","first-page":"132","volume":"28","author":"von Werssowetz AJ","year":"1948","journal-title":"J Vener Dis Inform"},{"key":"bibr-IJSA-10-243C98","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1949.01520260005001"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2010.010243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/ijsa.2010.010243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2010.010243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T06:12:25Z","timestamp":1740982345000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/ijsa.2010.010243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":98,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1258\/ijsa.2010.010243"],"URL":"https:\/\/doi.org\/10.1258\/ijsa.2010.010243","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}