{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:58:31Z","timestamp":1741067911732,"version":"3.38.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p> The aim of this study was to establish whether a combination of high-risk human papillomavirus (hrHPV) testing and cervical cytology could reduce colposcopy referral among women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion cytology. We randomized 598 women in the Helsinki area, Finland into three study groups. Different strategies of hrHPV testing, cytology and colposcopy with biopsy were used; subsequent hrHPV test results and cytological findings were compared with histology. The rates of hrHPV positivity and CIN2+ were compared. In total, 62.5% of all samples were hrHPV-positive. Altogether 45 (12.7%) CIN2 or worse (CIN2+) lesions were found in study groups A and B. Among hrHPV-positive women the rate of CIN2+ was 19.0% ( n = 43), in contrast with 1.6% ( n = 2) among hrHPV-negative women (relative risk = 12.2, 95% confidence interval [CI] 3.6\u201381.1, P &lt; 0.001). Among all hrHPV-negative women whose cytological findings were normal or ASCUS, dysplastic lesions were uncommon ( n = 4\/119, 3.4%), and all were CIN1. If these women had not been referred to colposcopy, the number of colposcopies would have been reduced by 33.6%. We conclude that hrHPV testing combined with repeat cervical cytology had a high negative predictive value in patients with recurrent low-grade cervical cytology. This could reduce the referral rate to colposcopy without jeopardizing patient safety. <\/jats:p>","DOI":"10.1258\/ijsa.2011.011336","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T07:00:11Z","timestamp":1343458811000},"page":"485-489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Colposcopy referral rate can be reduced by high-risk human papillomavirus triage in the management of recurrent atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion cytology in Finland"],"prefix":"10.1177","volume":"23","author":[{"given":"M","family":"Jakobsson","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital, Box 140, FI-00029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tarkkanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, HUSLAB, Helsinki University Hospital, Box 18, FI-01301, Vantaa, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Auvinen","sequence":"additional","affiliation":[{"name":"Department of Virology, Helsinki University Hospital Laboratory and Haartman Institute, University of Helsinki, Helsinki, Box 18, FI-01301, Vantaa, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"H\u00e4kkinen","sequence":"additional","affiliation":[{"name":"Finnish Forest Research Institute, Box 18, FI-01301, Vantaa, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Laurila","sequence":"additional","affiliation":[{"name":"Department of Pathology, HUSLAB, Helsinki University Hospital, Box 18, FI-01301, Vantaa, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Tapper","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital, Box 140, FI-00029"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"bibr1-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601185343"},{"key":"bibr2-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7451.1293"},{"key":"bibr3-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17354-6"},{"key":"bibr4-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80244-1"},{"key":"bibr5-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00636.x"},{"key":"bibr6-ijsa.2011.011336","unstructured":"Working Group set up by the Finnish Medical Society Duodecim and the Finnish Colposcopy Association. Diagnosis, treatment and follow-up of cytological changes in the cervix, vagina and vulva. 2006. See www.kaypahoito.fi (last accessed 08 June 2012)"},{"key":"bibr7-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.050"},{"key":"bibr8-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.461"},{"key":"bibr9-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.07.036"},{"key":"bibr10-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1080\/00365540500333566"},{"key":"bibr11-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380703"},{"key":"bibr12-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1258\/095646207782716910"},{"key":"bibr13-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.033"},{"key":"bibr14-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"bibr15-ijsa.2011.011336","doi-asserted-by":"crossref","first-page":"946","DOI":"10.5858\/2003-127-946-FTDFTA","volume":"127","author":"Schiffman M","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"bibr16-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp367"},{"key":"bibr17-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1804"},{"key":"bibr18-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq562"},{"key":"bibr19-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20140"},{"key":"bibr20-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024083"},{"key":"bibr21-ijsa.2011.011336","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00311-7"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2011.011336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/ijsa.2011.011336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/ijsa.2011.011336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T21:54:18Z","timestamp":1741038858000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/ijsa.2011.011336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1258\/ijsa.2011.011336"],"URL":"https:\/\/doi.org\/10.1258\/ijsa.2011.011336","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}