{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:19:11Z","timestamp":1773155951895,"version":"3.50.1"},"reference-count":8,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p> A 33-year-old man who developed progressive multifocal leukoencephalopathy (PML) with HIV infection is reported. The patient exhibited rapid decline in neurological status after initiation of antiretroviral therapy (ART), which was attributed to the PML-immune re-constitution inflammatory syndrome. Following the administration of mefloquine in combination with ART, the patient's neurological status improved substantially. This case suggests that further investigation of the use of mefloquine might be warranted for treatment of PML in HIV-infected patients. <\/jats:p>","DOI":"10.1258\/ijsa.2012.011305","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T10:08:32Z","timestamp":1346148512000},"page":"603-605","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient"],"prefix":"10.1177","volume":"23","author":[{"given":"E","family":"Adachi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Koibuchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Koga","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science"},{"name":"International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science"},{"name":"International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Miura","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science"},{"name":"Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, Research Hospital of The Institute of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"bibr-IJSA-11-305C1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.557"},{"key":"bibr-IJSA-11-305C2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01614-08"},{"key":"bibr-IJSA-11-305C3","doi-asserted-by":"publisher","DOI":"10.1086\/374048"},{"key":"bibr-IJSA-11-305C4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.190652"},{"key":"bibr-IJSA-11-305C5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3227"},{"key":"bibr-IJSA-11-305C6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c0d4a1"},{"key":"bibr-IJSA-11-305C7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343510.08643.74"},{"key":"bibr-IJSA-11-305C8","doi-asserted-by":"publisher","DOI":"10.1080\/13550280390195315"}],"container-title":["International Journal of STD &amp; 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