{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:54:21Z","timestamp":1760622861397,"version":"3.40.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>This study was conducted to determine the relationship between eosinophilia and parasitic infection in HIV-infected individuals. HIV-positive patients attending an HIV clinic in Birmingham were recruited and classified as either eosinophilic (&gt;400 eosinophils\/mm<jats:sup>3<\/jats:sup>) or non-eosinophilic. A demographic and parasitic risk history was taken and clinical examination was performed. Urine and stool were examined for parasites, and blood samples taken for parasite serology. A total of 266 patients (96 eosinophilic and 170 non-eosinophilic) were recruited. Of 64 eosinophilic patients who had a stool examination, one (1.6%) was positive for both Strongyloides larvae and schistosomal eggs. Urine microscopy was negative in the 245 patients (88 eosinophilic, 157 non-eosinophilic) from whom a sample was available. Two hundred and sixty-three patients underwent serological investigation (96 eosinophilic and 167 non-eosinophilic): 13 (4.9%) were positive for schistosomiasis and three (1.1%) positive for Strongyloides. A significant association between eosinophilia and positive schistosomal serology was found ( P = 0.003): 11 (10.5%) were eosinophilic patients, while only four (2.3%) were non-eosinophilic patients. Eosinophilia was associated with a low nadir CD4 count ( P = 0.021) and prior AIDS-defining illness ( P = 0.041). In all, 7.8% of patients from a developing country and 5.3% of patients from a developed country with a travel history had positive parasitic serology. Eosinophilia in HIV-infected patients was significantly associated with positive serology for schistosomiasis, low nadir CD4 count and prior AIDS-defining illness. Geographical exposure is also an important determinant of positive parasitic serology.<\/jats:p>","DOI":"10.1258\/ijsa.2012.011409","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T09:43:20Z","timestamp":1349171000000},"page":"635-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Eosinophilia: clinical significance in HIV-infected individuals"],"prefix":"10.1177","volume":"23","author":[{"given":"M","family":"Sivaram","sequence":"first","affiliation":[{"name":"Department of Genitourinary and HIV Medicine, Dartmouth Clinic, Sandwell General Hospital, Lyndon, West Bromwich, West Midlands B71 4HJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"White","sequence":"additional","affiliation":[{"name":"Department of Statistical Advisory Service, University of Birmingham, Edgbaston, Birmingham B15 2TT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K W","family":"Radcliffe","sequence":"additional","affiliation":[{"name":"Department of Genitourinary and HIV medicine, Queen Elizabeth Hospital and Whittall Street Clinic, Whittall Street, Birmingham B4 6DH,UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"bibr-IJSA-11-409C1","unstructured":"SidibeM. 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