{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T18:10:01Z","timestamp":1745086201839,"version":"3.40.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Early identification of patients co-infected with HIV and human T-lymphotropic virus type 1 (HTLV-1) is essential to improve care, as CD4+ T-cell counts have been revealed to be an unreliable laboratory parameter to monitor HIV infection in co-infection. Unfortunately, HTLV-1 testing is not currently available in sub-Saharan Africa. We conducted this study to determine the performance of absolute CD4+ T-cell count estimation in guiding the clinical suspicion of co-infection. A cross-sectional survey was conducted in antiretroviral-na\u00efve HIV (AN-HIV) patients attending an HIV outpatient clinic in Maputo city, Mozambique. Seven hundred and one AN-HIV patients were enrolled in the study. The prevalence of HTLV-1 co-infection was 4.5% (95% confidence interval [CI] 3.0\u20136.0%). Logistic regression analysis showed that CD4+ T-cell count was an independent predictor of co-infection ( P value: 0.000). The performance of absolute CD4+ T-cell counts in predicting co-infection was higher in symptomatic HIV patients when compared with asymptomatic HIV patients. The best performance was achieved with the cut-off of CD4+ count of 500 cells\/mm<jats:sup>3<\/jats:sup>, which gave sensitivity, specificity, positive and negative predictive values of 54.2%, 87.2%, 24.0% and 96.2%, respectively. In conclusion, our data provide evidence that the absolute CD4+ T-cell count is of moderate accuracy in guiding the clinical suspicion of co-infection in AN-HIV and its implementation could improve the care provided to a significant number of HIV patients in Mozambique.<\/jats:p>","DOI":"10.1258\/ijsa.2012.011446","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T15:21:48Z","timestamp":1351178508000},"page":"717-723","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Performance of absolute CD4+ count in predicting co-infection with human T-lymphotropic virus type 1 in antiretroviral-na\u00efve HIV-infected patients"],"prefix":"10.1177","volume":"23","author":[{"suffix":"Jr","given":"E S","family":"Gudo","sequence":"first","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, PO Box 264, Maputo, Mozambique"},{"name":"Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N B","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, PO Box 264, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Augusto","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, PO Box 264, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Sem\u00e1","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, PO Box 264, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Savino","sequence":"additional","affiliation":[{"name":"Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"O C","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I V","family":"Jani","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, PO Box 264, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr-IJSA-11-446C1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283217f9f"},{"key":"bibr-IJSA-11-446C2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208976"},{"key":"bibr-IJSA-11-446C3","doi-asserted-by":"publisher","DOI":"10.1128\/MR.60.4.722-742.1996"},{"key":"bibr-IJSA-11-446C4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208968"},{"key":"bibr-IJSA-11-446C5","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.71.153"},{"key":"bibr-IJSA-11-446C6","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.256"},{"key":"bibr-IJSA-11-446C7","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199504120-00012"},{"key":"bibr-IJSA-11-446C8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01730366"},{"key":"bibr-IJSA-11-446C9","unstructured":"WHO, Unicef. 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