{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:02:26Z","timestamp":1782363746956,"version":"3.54.5"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p> To assess whether human papillomavirus (HPV) testing is a safe enough approach to warrant extension of the screening intervals of baseline Papanicolaou (Pap)\u2212\/HPV\u2212 women in low-income settings. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Of the &gt;1000 women prospectively followed up as part of the Latin American Screening (LAMS) Study in S\u00e3o Paulo, Campinas, Porto Alegre) and Buenos Aires, 470 women with both baseline cytology and Hybrid Capture 2 (HC2) results available were included in this analysis. These baseline Pap-negative and HC2\u2212 or HC2+ women were controlled at six-month intervals with colposcopy, HC2 and Pap to assess the cumulative risk of incident Pap smear abnormalities and their predictive factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of the 470 women, 324 (68.9%) were high-risk HPV (hrHPV) positive and 146 (31.1%) were negative. Having two or more lifetime sex partners (odds ratio [OR] = 2.63; 95% CI 1.70\u20133.51) and women using hormonal contraception (OR = 2.21; 95% CI 1.40\u20133.51) were at increased risk for baseline hrHPV infection. Baseline hrHPV+ women had a significantly increased risk of incident abnormal Pap smears during the follow-up. Survival curves deviate from each other starting at month 24 onwards, when hrHPV+ women start rapidly accumulating incident Pap smear abnormalities, including atypical squamous cells (ASC) or worse (log-rank; P &lt; 0.001), low-grade squamous intraepithelial lesions (LSIL) or worse ( P &lt; 0.001) and high-grade squamous intraepithelial lesions (HSIL) ( P = 0.03). Among the baseline hrHPV\u2212 women, the acquisition of incident hrHPV during the follow-up period significantly increased the risk of incident cytological abnormalities (hazard ratio = 3.5; 95% CI 1.1\u201311.7). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> These data implicate that HPV testing for hrHPV types might be a safe enough approach to warrant extension of the screening interval of hrHPV\u2212\/Pap\u2212women even in low-resource settings. Although some women will inevitably contract hrHPV, the process to develop HSIL will be long enough to enable their detection at the next screening round (e.g. after three years). <\/jats:p><\/jats:sec>","DOI":"10.1258\/jms.2008.007061","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T21:18:37Z","timestamp":1213996717000},"page":"97-104","source":"Crossref","is-referenced-by-count":11,"title":["Safety of screening with Human papillomavirus testing for cervical cancer at three-year intervals in a high-risk population: experience from the LAMS study"],"prefix":"10.1177","volume":"15","author":[{"given":"S F","family":"Derchain","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, Brazil"},{"name":"Universidade Estadual de Campinas, Campinas, Brazil"},{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Brazil"},{"name":"Hospital Leonor M de Barros, S\u00e3o Paulo, Brazil"},{"name":"Instituto Adolfo Lutz, S\u00e3o 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