{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:22:58Z","timestamp":1757704978213,"version":"3.33.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p> To analyse the relationship between the false-positive\/false-negative predictive value (FPPV\/FNPV) of the HIV-antibody (HIV-Ab) test and prevalence in different Chinese population groups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> HIV prevalence among different population groups was obtained by a screening survey of blood donors and the national HIV\/AIDS surveillance programme in China. Given the sensitivity and specificity of a test kit and the prevalence of HIV infection, the estimated values of FPPV\/FNPV were calculated using Bayes' formula. The actual value of FPPV of blood donors was obtained by screening 1,195,286 blood donors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> This study indicates that the FPPV of HIV-Ab enzyme-linked immunosorbent assay (ELISA) assays varies widely in different Chinese populations: about 99.5% in the blood donor population, but only 3.2% in the injecting-drug users in high-risk areas. In 1,195,286 sera specimens from the blood donors, 2439 specimens were HIV-Ab positive by third ELISA, and 11 HIV cases were confirmed by Western blot. The HIV prevalence of the blood donor population in this survey was 0.0009% (11\/1,195,286), but the HIV-Ab positive rate of third ELISA is 0.2% (2439\/1,195,286) and 222 times higher than the prevalence. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Evaluation of HIV prevalence through the HIV-Ab positive rate by third ELISA will significantly overestimate the true prevalence in a low-prevalence population. Individual HIV-infection status should be taken into consideration when analysing the results of HIV-Ab tests in a population with low infection. <\/jats:p><\/jats:sec>","DOI":"10.1258\/jms.2008.007082","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T21:18:37Z","timestamp":1213996717000},"page":"72-75","source":"Crossref","is-referenced-by-count":7,"title":["The false-positive and false-negative predictive value of HIV antibody test in the Chinese population"],"prefix":"10.1177","volume":"15","author":[{"given":"Pei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Xuzhou Blood Center, Xuzhou 221002, Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Xuzhou Blood Center, Xuzhou 221002, Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Xuzhou Blood Center, Xuzhou 221002, Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Xuzhou Blood Center, Xuzhou 221002, Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, 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China"},{"name":"Xuzhou Blood Center, Xuzhou 221002, Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanbao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Xuzhou Blood Center, Xuzhou 221002, Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and 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Jiangsu, China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"},{"name":"Jiangsu Centers for Diseases Prevention and Control, Nanjing 210006, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"volume-title":"2005 Update on the HIV\/AIDS Epidemic and Response in China","year":"2006","author":"Ministry of Health of People's Republic of China, Joint United Nations Programme on HIV\/AIDS, World Health Organization","key":"bibr-JMS-07082C1"},{"key":"bibr-JMS-07082C2","first-page":"73","volume":"36","author":"Joon-Sup Y","year":"2006","journal-title":"Ann Clin Lab Sci"},{"key":"bibr-JMS-07082C3","first-page":"81","volume":"16","author":"Shu-wu Y","year":"2006","journal-title":"Chin J Health Lab Technol 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