{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:44:17Z","timestamp":1793889857920,"version":"4.8.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p> To determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Isfahan, the central state of Iran. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> From February to March 2006, a total of 2501 samples were screened for the quantitative measurement of G6PD activity by enzymatic colorimetric assay by a commercial kit (GAMMA, Belgium). The neonates were referred from 17 delivery units to the Isfahan neonatal screening center at 3\u20137 days after birth. Any neonate with a value &lt; 6.4 U\/gHb was considered G6PD deficient. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of the 2501 newborns (1307 males, 1194 females) screened, 79 neonates were found to have G6PD deficiency (67 males, 12 females). The overall incidence of G6PD deficiency was 3.2%. Frequency in male population was 5.1 % (67 out of 1307 male neonates) and in female population was 1% (12 out of 1194 female neonates).The female:male ratio was 1:5.5 ( P = 0.0001). The mean enzyme activity in deficient patients was 3.22 \u00b1 1.8 U\/gHb (male deficient group; 3.17 \u00b1 1.74 U\/gHb, female deficient group; 3.49 \u00b1 2.17 U\/gHb, P = 0.58). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Routine neonatal screening in Isfahan, Iran with a relatively high prevalence of G6PD deficiency is justified and meets the World Health Organization recommendation. <\/jats:p><\/jats:sec>","DOI":"10.1258\/jms.2008.008027","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T21:18:37Z","timestamp":1213996717000},"page":"62-64","source":"Crossref","is-referenced-by-count":13,"title":["Newborn screening for glucose-6-phosphate dehydrogenase deficiency in Isfahan, Iran: a quantitative assay"],"prefix":"10.1177","volume":"15","author":[{"given":"Ramin","family":"Iranpour","sequence":"first","affiliation":[{"name":"Neonatologist, Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, 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