{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:44:47Z","timestamp":1767156287947,"version":"3.38.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> To determine the ability of the quadruple Down's syndrome screening test (quad screen) to predict other adverse perinatal outcomes (APO) in a high-risk obstetric population. <\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p> A tertiary medical centre in West Virginia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We retrospectively reviewed 342 obstetric patients with quad screen data from a single clinic. The quad screen included maternal serum levels of alphafetoprotein (AFP), human chorionic gonadotrophin (hCG), uncongjugated oestriol (uE<jats:sub>3<\/jats:sub>), and inhibin A. The risk of APO was compared between patients with at least one abnormal marker versus no abnormal markers and \u22652 abnormal markers versus &lt;2 abnormal markers. Abnormal markers were determined by cut-off values produced by Receiver Operator Characteristic (ROC) curves and the FASTER trial. Unadjusted and adjusted effects were estimated using logistic regression analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The risk of having an APO increased significantly for patients with abnormal markers by about three-fold using ROC and two-fold using FASTER trial thresholds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The quad screen shows value in predicting risk of APO in high-risk patients. <\/jats:p><\/jats:sec>","DOI":"10.1258\/jms.2009.009017","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T19:28:39Z","timestamp":1246303719000},"page":"55-59","source":"Crossref","is-referenced-by-count":14,"title":["The Ability of the Quadruple Test to Predict Adverse Perinatal Outcomes in a High-risk Obstetric Population"],"prefix":"10.1177","volume":"16","author":[{"given":"Michael R","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston Area Medical Center, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron C","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston Area Medical Center, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A","family":"Bracero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston Area Medical Center, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Health Services & Outcomes Research, Charleston Area Medical Center Health Education and Research Institute, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dara J","family":"Seybold","sequence":"additional","affiliation":[{"name":"Center for Health Services & Outcomes Research, Charleston Area Medical Center Health Education and Research Institute, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Broce","sequence":"additional","affiliation":[{"name":"Center for Health Services & Outcomes Research, Charleston Area Medical Center Health Education and Research Institute, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos G","family":"Hatjis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northeast Ohio Universities College of Medicine, Rootstown, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,6,29]]},"reference":[{"key":"bibr1-jms.2009.009017","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.278"},{"key":"bibr2-jms.2009.009017","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.121727"},{"key":"bibr3-jms.2009.009017","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00108-4"},{"key":"bibr4-jms.2009.009017","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.114864"},{"key":"bibr5-jms.2009.009017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb09943.x"},{"key":"bibr6-jms.2009.009017","first-page":"531","volume":"99","author":"Baschat AA","year":"2002","journal-title":"Obstet 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