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This paper narrates the history of this treatment, describes Woolf's role in the establishment of neonatal PKU screening and surveys his other contributions to our understanding of this condition. If Woolf, Centerwall, Baird and Berry had waited until all the scientific evidence about PKU that is now at our disposal had been brought to light, there would still be no neonatal screening programmes.<\/jats:p>","DOI":"10.1258\/jms.2009.009062","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T22:33:46Z","timestamp":1262817226000},"page":"205-211","source":"Crossref","is-referenced-by-count":8,"title":["Article Commentary: The contributions of Louis I Woolf to the treatment, early diagnosis and understanding of phenylketonuria"],"prefix":"10.1177","volume":"16","author":[{"given":"J R","family":"Alonso-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Ms Chemist, Clinical Biochemistry Specialist, Health Sciences Associate Professor, Neonatal Screening Laboratory, Department of Paediatrics, University Hospital Complex (CHUS) and University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Col\u00f3n","sequence":"additional","affiliation":[{"name":"Pediatric Department, Neonatal Screening Laboratory, Department of Paediatrics, University Hospital Complex (CHUS) and University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1934.227.1-4.169"},{"key":"e_1_3_2_3_2","first-page":"1054","article-title":"Excretion of phenylpyruvic acid in urine as a metabolic anomaly in connection with imbecility.","volume":"8","author":"Falling A.","year":"1934","unstructured":"Falling A. 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