{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:56:11Z","timestamp":1768096571655,"version":"3.49.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To provide current population-based prevalence and prenatal diagnosis rates (PND) for specified major congenital anomalies in England and Wales to enable monitoring of the Fetal Anomaly Screening Programme (FASP). <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> Secondary analysis of prospectively collected registry data. <\/jats:p><\/jats:sec><jats:sec><jats:title>Setting:<\/jats:title><jats:p> Seven multiple-source, population-based congenital anomaly registers, members of the British Isles Network of Congenital Anomaly Registers (BINOCAR) in 2005 and 2006. <\/jats:p><\/jats:sec><jats:sec><jats:title>Population:<\/jats:title><jats:p> 2,883 births with congenital anomalies from a total of 601,545 live and stillbirths. <\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures:<\/jats:title><jats:p> PND and birth prevalence of selected congenital anomaly groups\/subtypes (anencephaly, spina-bifida, serious cardiac, diaphragmatic hernia, gastroschisis, exomphalos, bilateral renal agenesis, lethal\/severe skeletal dysplasia, cleft lip with or without cleft palate [CL + \/-P]). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of the selected anomaly groups, the most frequently reported were serious cardiac (14.1 per 10,000 births [95% CI 13.0-15.2]) and CL + \/-P (9.7 per 10,000 births [8.9-10.5]); the least frequent were bilateral renal agenesis and lethal\/severe skeletal dysplasia (&lt;1.5 per 10,000 births). The PND varied for different anomalies from 53.1% (95% CI 43.5-65.2) for serious cardiac anomalies to 99.6% (95% CI 97.9-100.0) for anencephaly. Least variation in PND rates was for anencephaly (range 98.9-100%) and gastroschisis (93.5-100%); greatest variation was for serious cardiac (43.5-65.2%) and lethal\/severe skeletal dysplasias (50.0-100%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> BINOCAR registers can, uniquely, provide contemporary data on PND and birth prevalence rates to enable monitoring of the ultrasound component of FASP at a national and regional level, allowing comparisons between populationstobemade, planningofresourcesfacilitatedand assistance for parents making informed decisions on whether to enter the screening programme. <\/jats:p><\/jats:sec>","DOI":"10.1258\/jms.2011.010139","type":"journal-article","created":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T16:23:26Z","timestamp":1304353406000},"page":"2-7","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":70,"title":["Monitoring the Prenatal Detection of Structural Fetal Congenital Anomalies in           England and Wales: Register-based Study"],"prefix":"10.1177","volume":"18","author":[{"given":"Patricia A","family":"Boyd","sequence":"first","affiliation":[{"name":"Congenital Anomaly Register for Oxfordshire, Berkshire and\r        Buckinghamshire, National Perinatal Epidemiology Unit, University of Oxford, Old Road\r        Campus, Oxford, OX3 7LF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M","family":"Tonks","sequence":"additional","affiliation":[{"name":"West Midlands Congenital Anomaly Register, West Midlands\r        Perinatal Institute, Crystal Court, Birmingham, B6 5RQ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Rankin","sequence":"additional","affiliation":[{"name":"Northern Congenital Abnormality Survey, Institute of Health and\r        Society, Newcastle University, Richardson Road, Newcastle upon Tyne, NE2 4AX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Rounding","sequence":"additional","affiliation":[{"name":"Congenital Anomaly Register for Oxfordshire, Berkshire and\r        Buckinghamshire, National Perinatal Epidemiology Unit, University of Oxford, Old Road\r        Campus, Oxford, OX3 7LF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Wellesley","sequence":"additional","affiliation":[{"name":"Wessex Antenatally Detected Anomalies Register (WANDA), Wessex\r        Clinical Genetics Service, Princess Anne Hospital, Southampton, SO16 5YA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S","family":"Draper","sequence":"additional","affiliation":[{"name":"East Midlands and South Yorkshire Congenital Anomaly Register,\r        University of Leicester, 22-28 Princess Road West, Leicester, LE1 6TP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Binocar Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,5,2]]},"reference":[{"key":"bibr1-jms.2011.010139","volume-title":"Human Malformations and Related Anomalies.","author":"Stevenson RE","year":"2006","edition":"2"},{"key":"bibr2-jms.2011.010139","volume-title":"Report of the RCOG Working Party on Routine Ultrasound in Pregnancy.","author":"Royal College of Obstetricians and Gynaecologists.","year":"1984"},{"key":"bibr3-jms.2011.010139","volume-title":"Ultrasound screening for fetal abnormalities: report of the RCOG working party.","author":"Royal College of Obstetricians and Gynaecologists.","year":"1997"},{"key":"bibr4-jms.2011.010139","volume-title":"Ultrasound Screening: supplement to Ultrasound Screening for Fetal Abnormalities.","author":"Royal College of Obstetricians and Gynaecologists.","year":"2000"},{"key":"bibr5-jms.2011.010139","volume-title":"Antenatal care: routine care for the healthy pregnant women NICE clinical guideline.","author":"National Institute for Clinical Excellence.","year":"2003"},{"key":"bibr6-jms.2011.010139","volume-title":"Antenatal care: routine care for the healthy pregnant women. 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