{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:57:07Z","timestamp":1793393827884,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p> Blood examination is a key element in studies of laboratory animals. In rodents, retrobulbar venous plexus puncture is a commonly used method for obtaining a blood sample. Although this technique yields large volumes of blood, the disadvantage is that it can lead to severe tissue damage. The aim of the present study was to develop the puncture of V. sublingualis as a suitable alternative technique for drawing blood in mice and other rodents. In rats, this method has been established for collecting large blood volumes. During the first part of the study, the sublingual bleeding technique was developed for use in mice and hamsters. Guineapigs, however, do not have a sublingual vein; therefore, in this species the method is not possible. In the second part of the study, retrobulbar and sublingual methods were compared using male CD-1 mice. When compared with the retrobulbar method, sublingual venepuncture showed less tissue destruction in mice, with a decreased mean severity in the histological examination. In conclusion, sublingual venepuncture can be recommended as a suitable, alternative blood collection technique, because of the reduced risk of tissue damage in mice and hamsters. <\/jats:p>","DOI":"10.1258\/la.2008.007073","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T18:22:19Z","timestamp":1240510939000},"page":"255-260","source":"Crossref","is-referenced-by-count":62,"title":["Blood collection from the sublingual vein in mice and hamsters: a suitable alternative to retrobulbar technique that provides large volumes and minimizes tissue damage"],"prefix":"10.1177","volume":"43","author":[{"given":"Maike","family":"Heimann","sequence":"first","affiliation":[{"name":"Novartis Pharma AG, Preclinical Safety, WKL-126.116, 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Peter","family":"K\u00e4sermann","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Pfister","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Preclinical Safety, 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Robert","family":"Roth","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Preclinical Safety, 4002 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"B\u00fcrki","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"bibr-LA-07-073C1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.727"},{"key":"bibr-LA-07-073C2","volume-title":"The Laboratory Mouse","author":"Suckow MA","year":"2001"},{"key":"bibr-LA-07-073C3","volume-title":"The Laboratory Hamster and Gerbil (a volume in the laboratory pocket reference series)","author":"Field KJ","year":"1999"},{"key":"bibr-LA-07-073C4","doi-asserted-by":"publisher","DOI":"10.1258\/002367798780599866"},{"key":"bibr-LA-07-073C5","volume-title":"Principles of Laboratory Animal Science","author":"Van Zutphen LFM","year":"2001"},{"key":"bibr-LA-07-073C6","volume-title":"Haus- und Versuchstierpflege","author":"Weiss J","year":"2003","edition":"2"},{"key":"bibr-LA-07-073C7","first-page":"11","volume":"74","author":"Pettit A","year":"1913","journal-title":"Comptes Rendus Biol"},{"key":"bibr-LA-07-073C8","first-page":"639","volume":"29","author":"McGee MA","year":"1979","journal-title":"Lab Anim Sci"},{"key":"bibr-LA-07-073C9","first-page":"135","volume":"2","author":"Messow C","year":"1980","journal-title":"AMI-Berichte"},{"key":"bibr-LA-07-073C10","doi-asserted-by":"publisher","DOI":"10.1258\/002367792780809048"},{"key":"bibr-LA-07-073C11","doi-asserted-by":"publisher","DOI":"10.1258\/002367798780599794"},{"key":"bibr-LA-07-073C12","unstructured":"US Department of Health and Human Services \u2013 National Institute of Health. Guidelines for Survival Bleedings of Mice and Rats. See http:\/\/oacu.od.nih.gov\/ARAC\/Bleeding.pdf (last accessed June 2007)"},{"key":"bibr-LA-07-073C13","unstructured":"Animal Care and Ethics Committee. Blood Collection in Rodents and Rabbits. University of Newcastle: ACEC, 1999:29. 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