{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:00:20Z","timestamp":1773291620239,"version":"3.50.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p> The NOD\/Shi- scid, IL-2R \u03b3<jats:sup>null<\/jats:sup> (NOG) mouse is a severely immunodeficient mouse used for the engraftment of human tissues and cells. In this study, 2406 mice (8\u201362 weeks old, 503 males and 1903 females) were subcutaneously engrafted with human tissues. In 16 mice (12\u201326 weeks old, 1 male and 15 females), a mass was seen in the anteroventralis of the thorax on gross examination with an incidence of 0.7%. Histologically, the masses were composed of sheets of lymphoblastic cells. A \u2018starry sky\u2019 pattern was observed with numerous mitoses. Immunohistochemically the lymphoblastic cells were positive for Thy 1. The lymphoblastic cells were also seen in the spleen, lung, liver, kidney and heart. The gross and histopathological findings led to the diagnosis of spontaneous thymic lymphoma in NOG mice. <\/jats:p>","DOI":"10.1258\/la.2009.009012","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:27:05Z","timestamp":1244507225000},"page":"402-404","source":"Crossref","is-referenced-by-count":27,"title":["Spontaneous thymic lymphomas in the non-obese diabetic\/Shi-<i>scid<\/i>, IL-2R<i>\u03b3<\/i><sup>null<\/sup> mouse"],"prefix":"10.1177","volume":"43","author":[{"given":"Chie","family":"Kato","sequence":"first","affiliation":[{"name":"PharmaLogicals Research Pte Ltd, 11 Biopolis Way, #05-08\/09 Helios, Singapore 138667, Singapore"},{"name":"Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Fujii","sequence":"additional","affiliation":[{"name":"PharmaLogicals Research Pte Ltd, 11 Biopolis Way, 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