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However, over the last five years, publications such as those from the Women's Health Initiative (WHI) have caused concern among women since they perceive that the risks outweigh the benefits. Following this publication, half of the women taking HRT in the UK, USA and New Zealand discontinued HRT. With the discontinuation of estrogen many women re-developed hot flushes; however only a small number (18%) of women report restarting hormone therapy. The majority of these (76%) for the recurrence of severe hot flushes or night sweats. Alternatives are available, but limited knowledge on aetiology and mechanisms of hot flushing represents a major obstacle for the development of new, targeted, non-hormonal treatments, and no current alternatives are as effective as estrogen.<\/jats:p>","DOI":"10.1258\/mi.2010.010007","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T18:24:24Z","timestamp":1282328664000},"page":"81-88","source":"Crossref","is-referenced-by-count":16,"title":["Hot flushes: are there effective alternatives to estrogen?"],"prefix":"10.1080","volume":"16","author":[{"given":"Jenifer","family":"Sassarini","sequence":"first","affiliation":[{"name":"Department of Developmental Medicine, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Lumsden","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, University of Glasgow, Glasgow, 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