{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:32:43Z","timestamp":1788539563036,"version":"build-2803163510"},"reference-count":44,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Menopause International"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>An ongoing need for safe and effective pharmacological therapies exists for postmenopausal osteoporosis, which imposes a significant burden on both women and the health-care system. Bazedoxifene is a novel selective estrogen receptor modulator with a unique tissue-selectivity profile. In phase 3 clinical trials of nearly 10,000 postmenopausal women, bazedoxifene was shown to significantly reduce the risk of new vertebral fracture versus placebo, with favourable effects on bone mineral density, bone turnover markers and the lipid profile. Moreover, in a subgroup of women at increased risk of fracture, bazedoxifene significantly decreased non-vertebral fracture risk versus both placebo and raloxifene. Bazedoxifene has been shown to be safe and well tolerated, with no evidence of endometrial or breast stimulation. These data suggest that bazedoxifene may offer significant clinical benefit for postmenopausal women with or at risk of developing osteoporosis, which may subsequently lessen the medical and economic burden of this disease.<\/jats:p>","DOI":"10.1258\/mi.2011.011011","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T06:23:13Z","timestamp":1308637393000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Bazedoxifene: a new selective estrogen receptor modulator for postmenopausal osteoporosis"],"prefix":"10.1080","volume":"17","author":[{"given":"Harry K","family":"Genant","sequence":"first","affiliation":[{"name":"University of California, San Francisco, CA, USA"},{"name":"Synarc, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"key":"bibr-MI-11-011C1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"bibr-MI-11-011C2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0340-1"},{"key":"bibr-MI-11-011C3","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000200248.34876.fe"},{"key":"bibr-MI-11-011C4","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000222475.93345.b3"},{"key":"bibr-MI-11-011C5","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1811-2"},{"key":"bibr-MI-11-011C6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.6953"},{"key":"bibr-MI-11-011C7","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629120-00005"},{"key":"bibr-MI-11-011C8","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1602-9"},{"key":"bibr-MI-11-011C9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.14.1344"},{"key":"bibr-MI-11-011C10","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730090-00003"},{"key":"bibr-MI-11-011C11","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0618-y"},{"key":"bibr-MI-11-011C12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.10.013"},{"key":"bibr-MI-11-011C13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.14.1701"},{"key":"bibr-MI-11-011C14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.13.1729"},{"key":"bibr-MI-11-011C15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.1.49"},{"key":"bibr-MI-11-011C16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.1.58"},{"key":"bibr-MI-11-011C17","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.3.6.681"},{"key":"bibr-MI-11-011C18","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.8.8750"},{"key":"bibr-MI-11-011C19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.7.637"},{"key":"bibr-MI-11-011C20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.23.joc60074"},{"key":"bibr-MI-11-011C21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062462"},{"key":"bibr-MI-11-011C22","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.518621"},{"key":"bibr-MI-11-011C23","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-006-1050-9"},{"key":"bibr-MI-11-011C24","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2004.tb05908.x"},{"key":"bibr-MI-11-011C25","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1680-8"},{"key":"bibr-MI-11-011C26","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0322-8"},{"key":"bibr-MI-11-011C27","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0466-1"},{"key":"bibr-MI-11-011C28","doi-asserted-by":"publisher","DOI":"10.4065\/81.8.1013"},{"key":"bibr-MI-11-011C29","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.12.018"},{"key":"bibr-MI-11-011C30","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0030"},{"key":"bibr-MI-11-011C31","volume":"16","author":"Ronkin S","year":"2001","journal-title":"J Bone Miner Res"},{"key":"bibr-MI-11-011C32","volume":"14","author":"Boudes P","year":"2003","journal-title":"Osteoporos Int"},{"key":"bibr-MI-11-011C33","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000163253.27610.b9"},{"key":"bibr-MI-11-011C34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-130"},{"key":"bibr-MI-11-011C35","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a818db"},{"key":"bibr-MI-11-011C36","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a7fb1e"},{"key":"bibr-MI-11-011C37","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071206"},{"key":"bibr-MI-11-011C38","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a816be"},{"key":"bibr-MI-11-011C39","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080710"},{"key":"bibr-MI-11-011C40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.02.014"},{"key":"bibr-MI-11-011C41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.01.373"},{"key":"bibr-MI-11-011C42","unstructured":"McCloskeyE, JohanssonH, OdenA, ChinesA, KanisJ. Assessment of the effect of bazedoxifene on non-vertebral fracture risk.\n                      J Bone Miner Res\n                      2009;\n                      24\n                      (Suppl 1). See http:\/\/www.asbmr.org\/Meetings\/AnnualMeeting\/AbstractDetail.aspx?aid=6c55b263-692e-4a37-b807-f7a153641564 (last checked 18 October 2010)"},{"key":"bibr-MI-11-011C43","unstructured":"SilvermanS, ChinesA, ZanchettaJR,  Sustained efficacy of bazedoxifene in preventing fractures in postmenopausal women with osteoporosis: results of a 5-year, randomized, placebo-controlled study.\n                      J Bone Miner Res\n                      2009;\n                      24\n                      (Suppl 1). 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