{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T08:40:16Z","timestamp":1786869616794,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p> Pregnancy associated with Wegener's granulomatosis is rare. Therapeutic options are limited. There is a paucity of published literature to guide clinical decision-making in these complex patients. Two cases are presented. Firstly, a 33-year-old woman with generalized Wegener's in remission and off all medications presented with a flare in the third trimester with haemoptysis, raised C-reactive protein and c-anti-neutrophilic cytoplasmic antibody (c-ANCA) levels. Her care was complicated by florid steroid-induced psychosis. With deteriorating disease control, she was treated with pulsed-intravenous cyclophosphamide with a good response. She delivered a healthy baby at 38 weeks. She had a severe postpartum flare. Secondly, a 37-year-old woman with limited Wegener's in remission for the last two years and off all treatment became pregnant after pre-conception counselling. A normal baby was delivered at term. An exhaustive review of all published literature on Wegener's activity in pregnancy is presented along with therapeutic options and recommendations. <\/jats:p>","DOI":"10.1258\/om.2009.080053","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T18:40:13Z","timestamp":1243017613000},"page":"77-80","source":"Crossref","is-referenced-by-count":13,"title":["Pregnancy complicating Wegener's granulomatosis"],"prefix":"10.1258","volume":"2","author":[{"given":"May Ching","family":"Soh","sequence":"first","affiliation":[{"name":"North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish H","family":"Hart","sequence":"additional","affiliation":[{"name":"North Shore Hospital, North Shore City, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Bass","sequence":"additional","affiliation":[{"name":"National Women's Health, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"National Women's Health, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"bibr-OM-08-0053-CPC1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.7.604"},{"key":"bibr-OM-08-0053-CPC2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199707)40:7<1354::AID-ART22>3.0.CO;2-M"},{"key":"bibr-OM-08-0053-CPC3","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(89)80121-3"},{"key":"bibr-OM-08-0053-CPC4","first-page":"70","volume":"37","author":"Zlotnikova AD","year":"1975","journal-title":"Arkh Patol"},{"key":"bibr-OM-08-0053-CPC5","first-page":"134","volume":"11","author":"Marinetti ELA","year":"1999","journal-title":"Int J Gynaecol Obstet"},{"key":"bibr-OM-08-0053-CPC6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1970.tb03452.x"},{"key":"bibr-OM-08-0053-CPC7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.7.1789"},{"key":"bibr-OM-08-0053-CPC8","first-page":"1153","volume":"21","author":"Pauzner R","year":"1994","journal-title":"J Rheumatol"},{"key":"bibr-OM-08-0053-CPC9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem391"},{"key":"bibr-OM-08-0053-CPC10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6702.791-a"},{"key":"bibr-OM-08-0053-CPC11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.10.800"},{"key":"bibr-OM-08-0053-CPC12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/6.2.139"},{"key":"bibr-OM-08-0053-CPC13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/03009742.1998.11720774","volume":"27","author":"Koldingsnes W","year":"1998","journal-title":"Scand J Rheumatol Suppl"},{"key":"bibr-OM-08-0053-CPC14","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0932-5"},{"key":"bibr-OM-08-0053-CPC15","doi-asserted-by":"publisher","DOI":"10.1080\/01443610600618374"},{"key":"bibr-OM-08-0053-CPC16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh353"},{"key":"bibr-OM-08-0053-CPC17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb02730.x"},{"key":"bibr-OM-08-0053-CPC18","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.3.331"},{"key":"bibr-OM-08-0053-CPC19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.03.054"},{"key":"bibr-OM-08-0053-CPC20","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270118"},{"key":"bibr-OM-08-0053-CPC21","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100099515"},{"key":"bibr-OM-08-0053-CPC22","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198412000-00030"},{"key":"bibr-OM-08-0053-CPC23","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.5.389"},{"key":"bibr-OM-08-0053-CPC24","first-page":"463","volume":"36","author":"Fields CL","year":"1991","journal-title":"J Reprod Med"},{"key":"bibr-OM-08-0053-CPC25","first-page":"332","volume":"46","author":"Habib A","year":"1996","journal-title":"Clin Nephrol"},{"key":"bibr-OM-08-0053-CPC26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.836"},{"key":"bibr-OM-08-0053-CPC27","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)00986-2"},{"key":"bibr-OM-08-0053-CPC28","first-page":"492","volume":"60","author":"Sahni V","year":"2005","journal-title":"Med J Malays"},{"key":"bibr-OM-08-0053-CPC29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.05.038"},{"key":"bibr-OM-08-0053-CPC30","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-008-0020-9"},{"key":"bibr-OM-08-0053-CPC31","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271118"},{"key":"bibr-OM-08-0053-CPC32","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2001.n.023"},{"key":"bibr-OM-08-0053-CPC33","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360404"},{"key":"bibr-OM-08-0053-CPC34","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(90)90042-T"},{"key":"bibr-OM-08-0053-CPC35","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/969826"},{"key":"bibr-OM-08-0053-CPC36","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701343024"},{"key":"bibr-OM-08-0053-CPC37","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306070970"},{"key":"bibr-OM-08-0053-CPC38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2004.06.003"},{"key":"bibr-OM-08-0053-CPC39","first-page":"451","volume":"76","author":"Watson WJ","year":"1990","journal-title":"Obstet Gynecol"},{"key":"bibr-OM-08-0053-CPC40","doi-asserted-by":"crossref","unstructured":"KlinikDT, van ElburgRM, SchreursMWJ, van WellGTJ. Rituximab administration in the third trimester of pregnancy suppresses neonatal B-cell development. Clin Develop Immunol 2008; DOI: 10.1155\/2008\/271363. Article ID 271363","DOI":"10.1155\/2008\/271363"},{"key":"bibr-OM-08-0053-CPC41","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-9-200511010-00005"},{"key":"bibr-OM-08-0053-CPC42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00821.x"},{"key":"bibr-OM-08-0053-CPC43","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92205-V"},{"key":"bibr-OM-08-0053-CPC44","first-page":"541","volume":"19","author":"Reinhold-Keller E","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"bibr-OM-08-0053-CPC45","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.2.147"},{"key":"bibr-OM-08-0053-CPC46","first-page":"S3","volume":"22","author":"Langford C","year":"2004","journal-title":"Clin Exp Rheumatol"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/om.2009.080053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/om.2009.080053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/om.2009.080053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T02:32:55Z","timestamp":1740969175000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/om.2009.080053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1258\/om.2009.080053"],"URL":"https:\/\/doi.org\/10.1258\/om.2009.080053","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}