{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:30:52Z","timestamp":1741152652446,"version":"3.38.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T00:00:00Z","timestamp":1285718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The purpose of this study was to compare the genetic background of superficial (SVT) and deep vein thrombosis (DVT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Factor V (FV)-Leiden (G16891A)-, factor II(G20210A)-mutations, protein C- and S, as well as methylenetetrahydrofolate reductase (MTHFR) polymorphisms at C677T and A1298C, and serum homocysteine levels (hcy) were determined in 29 patients with SVT and 26 with DVT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p> FV- and \u2013II-mutations were less frequent in patients with SVT (2\/3) compared with DVT (9\/5), respectively ( P &lt; 0.002 in case of FV). However, the frequency of the MTHFR C677T polymorphism was significantly higher in patients with SVT compared with DVT (CT 12 versus 10, and TT 7 versus 1, respectively, P &lt;&lt; 0.001). The distribution of the MTHFR A1298C genotype and serum hcy levels was similar in both patient groups. Protein S-deficiency was recorded once (SVT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p> These results suggest that the MTHFR C677T-mutant genetically predisposes its carriers to SVT which may contribute to hypercoagulation in pre-existing varicose vein disease. <\/jats:p><\/jats:sec>","DOI":"10.1258\/phleb.2009.009075","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T04:33:36Z","timestamp":1302669216000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase"],"prefix":"10.1177","volume":"26","author":[{"given":"C","family":"Wilmanns","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery and Phlebology, St. Elisabeth-Krankenhaus, Koblenzerstra\u00dfe 91, 54516 Wittlich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Phlebology, St. Elisabeth-Krankenhaus, Koblenzerstra\u00dfe 91, 54516 Wittlich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schinzel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Mainz, Langenbeckstra\u00dfe 1, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Phlebology, St. Elisabeth-Krankenhaus, Koblenzerstra\u00dfe 91, 54516 Wittlich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,9,29]]},"reference":[{"key":"bibr-PHLEB-09-075C1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615887"},{"key":"bibr-PHLEB-09-075C2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615180"},{"key":"bibr-PHLEB-09-075C3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2023"},{"key":"bibr-PHLEB-09-075C4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104253241701"},{"key":"bibr-PHLEB-09-075C5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540460039030"},{"key":"bibr-PHLEB-09-075C6","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000169946.31639.af"},{"key":"bibr-PHLEB-09-075C7","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.017244"},{"key":"bibr-PHLEB-09-075C8","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.5.497"},{"key":"bibr-PHLEB-09-075C9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07073.x"},{"key":"bibr-PHLEB-09-075C10","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1997.2638"},{"key":"bibr-PHLEB-09-075C11","doi-asserted-by":"publisher","DOI":"10.1177\/026835559501000202"},{"key":"bibr-PHLEB-09-075C12","first-page":"14","volume":"21","author":"Wilmanns C","year":"2009","journal-title":"Vasomed"},{"key":"bibr-PHLEB-09-075C13","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.8.619"},{"key":"bibr-PHLEB-09-075C14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.07.025"},{"key":"bibr-PHLEB-09-075C15","doi-asserted-by":"publisher","DOI":"10.1136\/jech.53.3.149"},{"key":"bibr-PHLEB-09-075C16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2005.06.005"}],"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/phleb.2009.009075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/phleb.2009.009075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/phleb.2009.009075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T09:26:09Z","timestamp":1741080369000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/phleb.2009.009075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,29]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1258\/phleb.2009.009075"],"URL":"https:\/\/doi.org\/10.1258\/phleb.2009.009075","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"type":"print","value":"0268-3555"},{"type":"electronic","value":"1758-1125"}],"subject":[],"published":{"date-parts":[[2010,9,29]]}}}