{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:33:53Z","timestamp":1791304433957,"version":"4.3.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> To evaluate the efficacy and safety of intralesional injection of pingyangmycin for the treatment of microcystic lymphatic malformations (LMs) in the tongue. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Eighteen patients with tongue microcystic LMs were treated with intralesional injection of pingyangmycin. The concentration of the drug was 1 mg\/mL with an addition of dexamethasone. Repeated injections were performed at an interval of 3\u20134 weeks. The results were evaluated by clinical examinations and Doppler ultrasonography scan. The follow-up period was 12 months to eight years after the last treatment and the mean follow-up time was three years. All patients received 1\u20138 injections (mean, 3.0 injections) for the whole course of treatment. The total dose of pingyangmycin administered was 8\u201364 mg (mean, 24 mg). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Fifteen patients had complete response with no cosmetic or functional problems. Three patients with macroglossia had a reduction of 50\u201390% in the lesion size and needed secondary surgery. No serious complications were encountered. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The results suggested that intralesional injection of pingyangmycin is an effective and safe treatment for microcystic LMs in the tongue, and can be used as the first-line treatment protocol. <\/jats:p><\/jats:sec>","DOI":"10.1258\/phleb.2011.011082","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T04:08:46Z","timestamp":1330574926000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue"],"prefix":"10.1177","volume":"28","author":[{"given":"H M","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao 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A","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X D","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"bibr1-phleb.2011.011082","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.10.1137"},{"key":"bibr2-phleb.2011.011082","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20768"},{"key":"bibr3-phleb.2011.011082","first-page":"253","volume":"26","author":"Fageeh N","year":"1997","journal-title":"J 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