{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:28:49Z","timestamp":1774686529694,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Accurate risk stratification soon after admission for patients with acute coronary syndromes (ACS) is vital in guiding management. Clinical risk scores and B-type natriuretic peptide (BNP) can predict mortality and re-infarction in ACS, but it is unknown whether BNP provides prognostic information over and above that of the clinical risk scores. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> 142 unselected patients with ACS were prospectively studied. BNP was measured and patients were stratified according to BNP and Global Registry of Acute Coronary Events (GRACE) score. In-hospital and 30-day events were characterised. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> 20.4% of ACS subjects had ST-elevation myocardial infarction (MI), 14.1%, non-ST elevation MI and 65.5% unstable angina. Elevated BNP predicted inhospital and 30-day heart failure (p&lt;0.01), and the risk of in-hospital recurrent ACS (p&lt;0.05). Increasing GRACE score predicted in-hospital recurrent ACS (p&lt;0.05), heart failure (p&lt;0.001), arrhythmias (p&lt;0.05) and angioplasty (p&lt;0.05). GRACE score also predicted 30-day heart failure (p&lt;0.05). In contrast, the predictive accuracy of troponin elevation was less robust. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> BNP and the GRACE score predict complementary outcomes from ACS, but both predicted heart failure. BNP is a powerful indicator of heart failure in patients with ACS and provides prognostic information above and beyond conventional biomarkers and risk scores. <\/jats:p><\/jats:sec>","DOI":"10.1258\/rsmsmj.52.3.8","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T22:08:12Z","timestamp":1300313292000},"page":"8-13","source":"Crossref","is-referenced-by-count":9,"title":["Predicting Outcome in Patients with Acute Coronary Syndrome: Evaluation of B-Type Natriuretic Peptide and the Global Registry of Acute Coronary Events (GRACE) Risk Score"],"prefix":"10.1177","volume":"52","author":[{"given":"H.","family":"Sinclair","sequence":"first","affiliation":[{"name":"Cardiovascular Research, The University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh, EH16 4SB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Paterson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research, The University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh, EH16 4SB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Walker","sequence":"additional","affiliation":[{"name":"Cardiovascular Research, The University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh, EH16 4SB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Beckett","sequence":"additional","affiliation":[{"name":"Cardiovascular Research, The University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh, EH16 4SB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.A.A.","family":"Fox","sequence":"additional","affiliation":[{"name":"Cardiovascular Research, The University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh, EH16 4SB"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,8,1]]},"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/rsmsmj.52.3.8","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/rsmsmj.52.3.8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T12:07:02Z","timestamp":1738066022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/rsmsmj.52.3.8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1258\/rsmsmj.52.3.8"],"URL":"https:\/\/doi.org\/10.1258\/rsmsmj.52.3.8","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}