{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:59:33Z","timestamp":1781765973898,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Critical lower limb ischaemia has an annual incidence of 500 \u2014 1000 per million and around a quarter will undergo a major lower limb amputation. Post operative pain and phantom pain are recognised complications. <\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p> The aim of this study was to assess the role of postoperative intraneural infusion of local anaesthetic in patients under-going major lower limb amputation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Between May 1998 and July 2001, following amputation patients either had standard post-operative analgesia or had an intra-neural infusion of 0.5% bupivicaine via an infant feeding catheter connected to a standard syringe pump (Alaris\u00ae). This was a retrospective review and clinical notes of these patients were analysed to assess their post operative course, analgesic requirements and to ascertain phantom limb pain\/sensation rates. All the data collected was from standard drug charts, case note entries and out-patient letters. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> During this time period 64 patients had a major lower limb amputation (31 patients treated routinely and 33 patients had an intra-neural anaesthetic (INA) catheter placed). In the INA group median post-operative opioid analgesia requirement was 10mg versus 74mg (p=0.0002, Mann-Whitney U) and post-operative prescription of amitriptyline for phantom pain was less common (4 patients versus 11 patients; p=0.0281, Mann-Whitney U). There was no obvious increase in complications or significant adverse events. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Postoperative intra-neural local anaesthetic infusion is a safe and effective technique. It reduces post-operative opioid analgesia requirement and seems to reduce phantom pain development. <\/jats:p><\/jats:sec>","DOI":"10.1258\/rsmsmj.53.1.4","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T22:08:12Z","timestamp":1300313292000},"page":"4-6","source":"Crossref","is-referenced-by-count":37,"title":["The Effect of Intra-Neural Local Anaesthetic Infusion on Pain Following Major Lower Limb Amputation."],"prefix":"10.1177","volume":"53","author":[{"given":"AJ","family":"Grant","sequence":"first","affiliation":[{"name":"Department of Surgery, Raigmore Hospital, Old Perth Road, Inverness, IV2 3UJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"bibr1-RSMSMJ.53.1.4","unstructured":"Davies AH, Beard JD, Wyatt MG eds. Essential Vascular Surgery. London. WB Saunders, 1999. 18\u201330."},{"key":"bibr2-RSMSMJ.53.1.4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/096721099400200615","volume":"2","author":"Schina MJ","year":"1994","journal-title":"Cardiovasc Surg"},{"key":"bibr3-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200204000-00010"},{"key":"bibr4-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198703000-00027"},{"key":"bibr5-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00074-1"},{"key":"bibr6-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200107000-00007"},{"key":"bibr7-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/81.3.348"},{"key":"bibr8-RSMSMJ.53.1.4","first-page":"324","volume":"76","author":"Jahangiri M","year":"1994","journal-title":"Ann R Coll Surg Eng"},{"key":"bibr9-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-7339(97)80011-9"},{"key":"bibr10-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200204000-00032"},{"key":"bibr11-RSMSMJ.53.1.4","first-page":"179","volume":"31","author":"Elizaga AM","year":"1994","journal-title":"J Rehabil Res Dev"},{"key":"bibr12-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199610000-00007"},{"issue":"266","key":"bibr13-RSMSMJ.53.1.4","first-page":"227","author":"Malawer MM","year":"1991","journal-title":"Clin Orthop Rel Res"},{"key":"bibr14-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199103000-00004"},{"key":"bibr15-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.70B1.3257494"},{"key":"bibr16-RSMSMJ.53.1.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00061-4"},{"key":"bibr17-RSMSMJ.53.1.4","first-page":"211","volume":"69","author":"Bloomquist T.","year":"2001","journal-title":"AANA J"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/RSMSMJ.53.1.4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/RSMSMJ.53.1.4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T22:31:47Z","timestamp":1741041107000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/RSMSMJ.53.1.4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1258\/RSMSMJ.53.1.4"],"URL":"https:\/\/doi.org\/10.1258\/rsmsmj.53.1.4","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}