{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:49:43Z","timestamp":1769611783121,"version":"3.49.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> In 2003 an estimated 37,500 of Scotland's population was chronically infected with HCV; 44% were undiagnosed former injecting drug users (IDU) - a priority group for antiviral therapy <\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p> To evaluate a hepatitis C virus (HCV) screening intervention <\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p> Outcome measures among two similar General Practice populations in an area of high HCV and drug use prevalence, one of which was exposed to an HCV screening intervention, were compared <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Thirty to fifty four year old attendees of the intervention practice were opportunistically offered testing and counselling, where clinically appropriate, (November 2003\u2013 April 2004) Outcomes: HCV test uptake, case detection, referral and treatment administration rates. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of 584 eligible attendees, 421 (72%) were offered and 117 (28%) accepted testing in the intervention practice; no testing was undertaken in the comparison practice Prevalences of HCV antibody were 13% (15\/117), 75% (3\/4) and 91% (10\/11) among all tested persons, current IDUs and former IDUs respectively. For 4\/15 (27%) evidence of binge drinking following the receipt of their positive result, was available. Of the 11 referred to specialist care because they were HCV RNA positive, nine attended at least one appointment. Two received treatment: one had achieved a sustained viral response as of February 2008. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> While non targeted HCV screening in the general practice setting can detect infected former IDU, the low diagnostic yield among non IDUs limited the effectiveness of the intervention. A more targeted approach for identifying former IDUs is recommended. Additionally, the low uptake of treatment among chronically infected persons four years after diagnosis demonstrates the difficulties in clinically managing such individuals. Strategies, including support for those with a history of problem alcohol use, to improve treatment uptake are required. <\/jats:p><\/jats:sec>","DOI":"10.1258\/rsmsmj.54.3.3","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T22:08:12Z","timestamp":1300313292000},"page":"3-7","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of a General Practice Based Hepatitis C Virus Screening Intervention"],"prefix":"10.1177","volume":"54","author":[{"given":"Em","family":"Anderson","sequence":"first","affiliation":[{"name":"Public Health Protection Unit, NHS Greater Glasgow and Clyde, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rp","family":"Mandeville","sequence":"additional","affiliation":[{"name":"Keppoch Medical Practice, Possilpark Health Centre, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sj","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Health Protection Scotland, Glasgow, UK. Department of Statistics and Modelling Science, University of Strathclyde, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Cameron","sequence":"additional","affiliation":[{"name":"West of Scotland Specialist Virology Centre, Gartnavel General Hospital, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pr","family":"Mills","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Gartnavel General Hospital, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fox","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, The Brownlee Centre, Gartnavel General Hospital, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Public Health Protection Unit, NHS Greater Glasgow and Clyde, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute for Applied Social and Health Research and Associate Dean (Research and Commercialisation) School of Social Sciences, University of the West of Scotland, Paisley Campus, Paisley, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Spence","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Gartnavel General Hospital, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dj","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Health Protection Scotland, Glasgow, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"bibr1-RSMSMJ.54.3.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2004.00570.x"},{"key":"bibr2-RSMSMJ.54.3.3","first-page":"21","volume":"10","author":"Wright M","year":"2006","journal-title":"HTA"},{"key":"bibr3-RSMSMJ.54.3.3","first-page":"11","volume":"11","author":"Shepherd J","year":"2007","journal-title":"HTA"},{"key":"bibr4-RSMSMJ.54.3.3","doi-asserted-by":"publisher","DOI":"10.1258\/RSMSMJ.51.2.8"},{"key":"bibr5-RSMSMJ.54.3.3","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10463"},{"key":"bibr6-RSMSMJ.54.3.3","first-page":"359","volume":"23","author":"Altman C","year":"1999","journal-title":"Gastroenterol Clin Biol"},{"key":"bibr7-RSMSMJ.54.3.3","first-page":"1037","volume":"24","author":"Roudot-Thoraval F","year":"2000","journal-title":"Gastroenterol Clin Biol"},{"key":"bibr8-RSMSMJ.54.3.3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010902614443"},{"key":"bibr9-RSMSMJ.54.3.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(04)94935-4"},{"key":"bibr10-RSMSMJ.54.3.3","first-page":"541","volume":"24","author":"Monnet E.","year":"2000","journal-title":"Gastroenterologie Clinique et Biologique"},{"key":"bibr11-RSMSMJ.54.3.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7106.453"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/RSMSMJ.54.3.3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/RSMSMJ.54.3.3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T13:12:22Z","timestamp":1740834742000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/RSMSMJ.54.3.3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1258\/RSMSMJ.54.3.3"],"URL":"https:\/\/doi.org\/10.1258\/rsmsmj.54.3.3","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}