{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:28:22Z","timestamp":1754396902543,"version":"3.38.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p> The expected duration of initial antiparkinson monotherapy before the need for supplementation is not clearly defined for routine practice. The aim of this study was to define the length of l-dopa (L-3, 4-dihydrophenylalanine) and dopamine agonist monotherapy. The duration of monotherapy and discontinuation rates were investigated in a natural observational setting by plotting Kaplan\u2013Meier survival curves. Out of 345 patients, 180 (52.2%) received l-dopa and 165 (47.8%) received a dopamine agonist as initial monotherapy. Half of the patients starting l-dopa received supplementary therapy within 3.6 years (95% confidence interval, 3.2-4.6), significantly longer than for dopamine agonist monotherapy (half required a second agent at 2.3 years [2.0-2.9]; P = 0.00017). Discontinuation of l-dopa therapy was 1%. Dopamine agonists were stopped (due to side-effects like impulse control disorders [6%], somnolence [4%] and light-headedness [3%]) in 20% over four years. The duration and tolerability of l-dopa and dopamine agonists as initial Parkinson's disease monotherapy are defined in this study; this may form part of the information exchange with patients. <\/jats:p>","DOI":"10.1258\/smj.2012.012121","type":"journal-article","created":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:14:14Z","timestamp":1348359254000},"page":"217-220","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Duration of l-dopa and dopamine agonist monotherapy in Parkinson's disease"],"prefix":"10.1177","volume":"57","author":[{"given":"T","family":"Nissen","sequence":"first","affiliation":[{"name":"Department of Neurology, Klinikum Bremerhaven, Bremerhaven, Germany"},{"name":"Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E 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