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Macrolides are equally efficacious and have less adverse effects, but they are expensive. Azithromycin is the recommended drug in pregnancy and for children. Rifampicin is effective in areas where doxycycline resistance is present. Quinolones have shown some degree of efficacy but the evidence is scant. Most clinical evidence on drug treatment is from cases of mild-to-moderate scrub typhus. Further study is needed on the efficacy of different antibiotics in the treatment of severe, life-threatening scrub typhus. <\/jats:p>","DOI":"10.1258\/td.2010.100311","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T23:18:52Z","timestamp":1292627932000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Drug treatment of scrub typhus"],"prefix":"10.1177","volume":"41","author":[{"given":"Senaka","family":"Rajapakse","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaturaka","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"University Medical Unit, National Hospital, Regent Street, Colombo 08"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumadhya Deepika","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"bibr-TD-10-0311C1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.7883\/yoken.JJID.2008.148","volume":"61","author":"Bang HA","year":"2008","journal-title":"Jpn J Infect Dis"},{"key":"bibr-TD-10-0311C2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01352-6"},{"key":"bibr-TD-10-0311C3","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-38.2.308"},{"key":"bibr-TD-10-0311C4","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200310000-00009"},{"key":"bibr-TD-10-0311C5","doi-asserted-by":"publisher","DOI":"10.1086\/313906"},{"key":"bibr-TD-10-0311C6","unstructured":"Scrubtyphus. eMedicine 2009 (cited 2009 Oct 16). 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