{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:10:51Z","timestamp":1789729851233,"version":"4.0.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:00:00Z","timestamp":1333411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p> The aim of this study was to assess incidence and risk factors for acute kidney injury (AKI) in patients with dengue fever (DF). A total of 223 patients (males, 130; females, 93; mean age, 26.2 \u00b1 18.2 years) from a tertiary care centre in southern India were retrospectively analysed. Acute renal failure (ARF) developed in 24 (10.8%) patients. Based on the Acute Kidney Injury Network (AKIN) criteria, the results revealed that: 12 (5.4%) had mild AKI; seven (3.1%) had moderate AKI; and five (2.2%) had severe AKI. A further 54 (24%) were diagnosed with dengue haemorrhagic fever (DHF); 11 (5%) were co-infected with leptospirosis; thrombocytopenia was present in 157 (70%); and 64 (29%) were hypotensive. Patients were divided into either group A (with AKI) or group B (without AKI), and group A was divided into mild (A1), moderate (A2) and severe (A3) subgroups. We recorded: a higher total white count (A = 9824; B = 6706; P = 0.01); serum glutamic pyruvic transaminase (SGPT; A = 450; B = 144; P = 0.001); alkaline phosphatase (ALP) levels (A = 207; B = 42; P = 0.001); lower albumin (A = 2.65; B = 3.09; P &lt; 0.001); and serum bicarbonate (A = 20.57; B = 23.21; P = 0.009). Hypotension ( P = 0.01), coexisting viral hepatitis ( P &lt; 0.001), sepsis ( P &lt; 0.001), multiple organ dysfunction syndrome (MODS; P &lt; 0.001) and the need for inotropes ( P &lt; 0.001) were associated with DF. Total white count ( P = 0.038), glomerular filtration rate (GFR) on discharge ( P = 0.034), specific gravity of urine ( P = 0.006), ALP ( P = 0.013), SGPT ( P = 0.042), MODS ( P = 0.05) and use of platelet fresh frozen plasma (FFP; P = 0.007) were significantly different between mild, moderate and severe AKI subgroups. Twenty-two (9%) died. AKI is associated with an increased mortality in DF ( P = 0.005). <\/jats:p>","DOI":"10.1258\/td.2012.120023","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T05:50:21Z","timestamp":1333518621000},"page":"160-162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Acute kidney injury in dengue fever using Acute Kidney Injury Network criteria: incidence and risk factors"],"prefix":"10.1177","volume":"42","author":[{"given":"Nikita","family":"Mehra","sequence":"first","affiliation":[{"name":"Sri Ramachandra University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amish","family":"Patel","sequence":"additional","affiliation":[{"name":"Sri Ramachandra University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgi","family":"Abraham","sequence":"additional","affiliation":[{"name":"Madras Medical Mission, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh N V","family":"Reddy","sequence":"additional","affiliation":[{"name":"Madras Medical Mission, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuvaram N V","family":"Reddy","sequence":"additional","affiliation":[{"name":"Sri Ramachandra University, Chennai, India"},{"name":"Madras Medical Mission, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,4,3]]},"reference":[{"key":"bibr-TD-12-0023C1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7353.1563"},{"key":"bibr-TD-12-0023C2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)12483-7"},{"key":"bibr-TD-12-0023C3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"bibr-TD-12-0023C4","unstructured":"Acute Kidney Injury Network. AKIN Studies. 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