{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:50:55Z","timestamp":1761058255314,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:p> Objective: To evaluate the association between the 4G\/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene and deep venous thrombosis (DVT) in young people. <\/jats:p><jats:p> Methods: Prevalence of the 4G\/5G polymorphism was investigated using DNA analysis in a population of 81 consecutive and unrelated patients with an objectively documented first episode of DVT under 40 years old and in a control group of 88 healthy subjects. <\/jats:p><jats:p> Results: The frequency of genotypes among patients was 0.27 4G\/4G, 0.49 4G\/5G and 0.23 5G\/5G, corresponding to a frequency of 0.52 for the 4G allele. In the control group the results were, respectively, 0.24, 0.44 and 0.32, corresponding to a frequency of 0.46 for the 4G allele. The odds ratio (OR) for homozygous 4G genotype was 1.5 (95% confidence interval: 0.7\u20133.6), which was not statistically significant ( P = 0.51). <\/jats:p><jats:p> Conclusion: In this study, the 4G\/5G polymorphism in the promoter of the PAI-1 gene, including the homozygous 4G genotype, was not associated with a significantly increased risk of DVT in young people. <\/jats:p>","DOI":"10.1258\/0268355053300857","type":"journal-article","created":{"date-parts":[[2005,3,31]],"date-time":"2005-03-31T23:57:52Z","timestamp":1112313472000},"page":"48-52","source":"Crossref","is-referenced-by-count":8,"title":["The association between the 4G\/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 gene and deep venous thrombosis in young people"],"prefix":"10.1177","volume":"20","author":[{"given":"A","family":"Mansilha","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Porto, Portugal"}]},{"given":"F","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, Molecular Biology Centre, Porto, Portugal"}]},{"given":"M","family":"Severo","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, S. Jo\u00e3o University Hospital, Porto, Portugal"}]},{"given":"S M","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Porto, Portugal"}]},{"given":"T","family":"Toledo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Porto, Portugal"}]},{"given":"I","family":"Henriques","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, Molecular Biology Centre, Porto, Portugal"}]},{"given":"R","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2005,3,1]]},"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0268355053300857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0268355053300857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:57:01Z","timestamp":1741111021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0268355053300857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,3,1]]}},"alternative-id":["10.1258\/0268355053300857"],"URL":"https:\/\/doi.org\/10.1258\/0268355053300857","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"type":"print","value":"0268-3555"},{"type":"electronic","value":"1758-1125"}],"subject":[],"published":{"date-parts":[[2005,3,1]]}}}