{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:57:05Z","timestamp":1773662225952,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:p> Objective: To evaluate the association between the Factor V Leiden (FV R506Q) and prothrombin gene (FII G20210A) mutations and deep venous thrombosis (DVT) in young people. <\/jats:p><jats:p> Methods: Blood samples were drawn from 199 subjects: 100 healthy controls and 99 unselected patients, with an objectively documented first episode of DVT under 40 years old. DNA analysis was performed using the polymerase chain reaction. <\/jats:p><jats:p> Results: The mean age in the patient cohort was 27 years (range 16\u201340) and 68 (68.7%) were women. Patient prevalences were 20.6% and 10.1% for FV R506Q and FII G20210A, respectively. In the control group, carrier frequencies were 2% and 5%, respectively. We found an increased overall relative risk of DVT with statistical significance for FV R506Q carriers (OR: 12.8; 95% CI: 2.9\u201356.7; P &lt; 0.001), but not for FII G20210A mutation (OR: 2.1; 95% CI: 0.7\u20136.5; P = 0.19). <\/jats:p><jats:p> Conclusions: Our results suggest a possible increase in DVT risk for the young G20210A allele carriers, which can be more expressed in the presence of a circumstantial risk factor. There is extremely strong evidence that the Factor V Leiden mutation is an important risk factor in the development of a first episode of DVT in young people. <\/jats:p>","DOI":"10.1258\/026835506775971171","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T21:41:27Z","timestamp":1140644487000},"page":"24-27","source":"Crossref","is-referenced-by-count":4,"title":["Combined Factor V Leiden (R506Q) and prothrombin G20210A genotyping in young patients presenting with deep venous thrombosis"],"prefix":"10.1177","volume":"21","author":[{"given":"A","family":"Mansilha","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Molecular Biology Centre, S Jo\u00e3o University Hospital, Porto, Portugal"}]},{"given":"F","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, Molecular Biology Centre, S Jo\u00e3o University Hospital, Porto, Portugal"}]},{"given":"M","family":"Severo","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, S Jo\u00e3o University Hospital, Porto, Portugal"}]},{"given":"S M","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Molecular Biology Centre, S Jo\u00e3o University Hospital, Porto, Portugal"}]},{"given":"T","family":"Toledo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Molecular Biology Centre, S Jo\u00e3o University Hospital, Porto, Portugal"}]},{"given":"R","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Molecular Biology Centre, S Jo\u00e3o University Hospital, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2006,3,1]]},"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/026835506775971171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/026835506775971171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T21:11:41Z","timestamp":1741036301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/026835506775971171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,3,1]]}},"alternative-id":["10.1258\/026835506775971171"],"URL":"https:\/\/doi.org\/10.1258\/026835506775971171","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"value":"0268-3555","type":"print"},{"value":"1758-1125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,1]]}}}