{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:36:15Z","timestamp":1759847775316},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1019","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>It is widely accepted that the diagnosis of foetal central nervous system (CNS) abnormalities can be improved by performing MRI examinations in utero. Most of the published literature has concentrated on pregnancies in which a developmental abnormality has been detected (or suspected) on ultrasound in an otherwise low-risk pregnancy. In this paper, we test the hypothesis that in utero MRI of the foetal brain in high-risk pregnancies will detect abnormalities not shown by ultrasound at a rate that justifies its use in clinical practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>100 females were recruited into the study from foeto-maternal or clinical genetic departments. They all had a foetus\/child with a CNS malformation from an earlier pregnancy, which led to an increased risk of recurrence being quoted for the present pregnancy. All in utero MRI examinations were performed on 1.5 T clinical MRI systems at 18 weeks gestational age or later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 78% of cases, the ultrasound and MRI results agreed and showed no abnormality. In 13%, ultrasound and MRI described identical abnormal findings. In 9%, the ultrasound and MRI examinations had discrepant findings; in all these cases the MRI findings described more serious CNS pathology. The effects on management were judged to be major, by at least one assessor, in 7\/9 of those cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>As in many other situations involving antenatal detection of CNS abnormalities, in utero MRI should be considered in females with increased risk of foetal CNS malformation based on the results of an earlier pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>In utero MRI of the foetus has an important role in antenatal diagnosis of females carrying a foetus with an increased risk of a brain abnormality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr\/23696508","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T07:49:24Z","timestamp":1341474564000},"page":"e1038-e1045","source":"Crossref","is-referenced-by-count":17,"title":["The use of <i>in utero<\/i> MRI to supplement ultrasound in the foetus at high risk of developmental brain or spine abnormality"],"prefix":"10.1093","volume":"85","author":[{"given":"P D","family":"Griffiths","sequence":"first","affiliation":[{"name":"Academic Unit of Radiology, University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Porteous","sequence":"additional","affiliation":[{"name":"SE Scotland Genetic Service, Western General Hospital, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Feto-Maternal Medicine, Leeds General Infirmary, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Russell","sequence":"additional","affiliation":[{"name":"Radiology Department, St Mary's Hospital, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Morris","sequence":"additional","affiliation":[{"name":"Academic Unit of Radiology, University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Fanou","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospital of North Staffordshire, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Reeves","sequence":"additional","affiliation":[{"name":"Academic Unit of Radiology, University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"2024050213260658900_b1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3174\/ajnr.A1767","article-title":"A prospective study of fetuses with isolated ventriculomegaly investigated by ante-natal ultrasound and in utero MR.","volume":"31","author":"Griffiths","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024050213260658900_b2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1471-0528.2004.00149.x","article-title":"Outcome of 100 singleton pregnancies with suspected brain abnormalities diagnosed on ultrasound and investigated by in utero MR imaging.","volume":"111","author":"Whitby","year":"2004","journal-title":"BJOG"},{"key":"2024050213260658900_b3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1148\/radiology.204.3.9280237","article-title":"Fetal central nervous system anomalies: MR imaging augments sonographic diagnosis.","volume":"204","author":"Levine","year":"1997","journal-title":"Radiology"},{"key":"2024050213260658900_b4","first-page":"1688","article-title":"Fast MR imaging of fetal CNS anomalies in utero.","volume":"21","author":"Simon","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024050213260658900_b5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.nic.2004.03.006","article-title":"Fetal imaging of CNS abnormalities.","volume":"14","author":"Golja","year":"2004","journal-title":"Neuroimag Clin N Am"},{"key":"2024050213260658900_b6","first-page":"723","article-title":"Cerebral fetal MRI and ventriculomegaly. [In French.]","volume":"83","author":"Launay","year":"2002","journal-title":"J Radiol"},{"key":"2024050213260658900_b7","first-page":"367","article-title":"Congenital malformations of the brain and skull.","author":"Simon Swartz","year":"2011","journal-title":"Pediatric neuroimaging"},{"key":"2024050213260658900_b8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/pd.2195","article-title":"The significance of fetal ventriculomegaly: etiology, short and long term outcomes.","volume":"29","author":"Gaglioti","year":"2009","journal-title":"Prenat Diagn"},{"key":"2024050213260658900_b9","doi-asserted-by":"crossref","first-page":"F208","DOI":"10.1136\/adc.2003.041392","article-title":"Perinatal pathology in the context of a clinical trial: attitudes of bereaved parents.","volume":"89","author":"Snowdon","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2024050213260658900_b10","doi-asserted-by":"crossref","first-page":"F204","DOI":"10.1136\/adc.2002.012732","article-title":"Perinatal pathology in the context of a clinical trial: attitudes of neonatologists and pathologists.","volume":"89","author":"Snowdon","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2024050213260658900_b11","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0140-6736(05)74816-9","article-title":"Post mortem MRI as an adjunct to fetal or neonatal autopsy.","volume":"365","author":"Griffiths","year":"2005","journal-title":"Lancet"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/85\/1019\/e1038\/57385063\/bjr_23696508.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/85\/1019\/e1038\/57385063\/bjr_23696508.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T13:27:31Z","timestamp":1714656451000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/85\/1019\/e1038\/7450538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":11,"journal-issue":{"issue":"1019","published-online":{"date-parts":[[2014,1,28]]},"published-print":{"date-parts":[[2012,11,1]]}},"URL":"https:\/\/doi.org\/10.1259\/bjr\/23696508","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,11,1]]},"published":{"date-parts":[[2012,11,1]]}}}