{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:59:36Z","timestamp":1763017176516,"version":"3.40.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1016","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>Objective: To determine the role of abdominal CT in assessment of severity and prognosis of patients with acute gastrointestinal (GI) graft-vs-host disease (GVHD).<\/jats:p><jats:p>Methods: During 2000\u20132004, 41 patients with a clinical diagnosis of acute GI-GVHD were evaluated. CTs were examined for intestinal and extra-intestinal abnormalities, and correlated with clinical staging and outcome.<\/jats:p><jats:p>Results: 20 patients had GVHD clinical Stage I\u2013II and 21 had Stage III\u2013IV. 39 (95%) had abnormal CT appearances. The most consistent finding was bowel wall thickening: small (n=14, 34%) or large (n=5, 12%) bowel, or both (n=20, 49%). Other manifestations included bowel dilatation (n=7, 17%), mucosal enhancement (n=6, 15%) and gastric wall thickening (n=9, 38%). Extra-intestinal findings included mesenteric stranding (n=25, 61%), ascites (n=17, 41%), biliary abnormalities (n=12, 29%) and urinary excretion of orally administered gastrografin (n=12, 44%). Diffuse small-bowel thickening and any involvement of the large bowel were associated with severe clinical presentation. Diffuse small-bowel disease correlated with poor prognosis. 8 of 21 patients responded to therapy, compared with 15 of 20 patients with other patterns (p=0.02), and the cumulative incidence of GVHD-related death was 62% and 24%, respectively (p=0.01). Overall survival was not significantly different between patients with diffuse small-bowel disease and patients with other patterns (p=0.31). Colonic disease correlated with severity of GVHD (p=0.04), but not with response to therapy or prognosis (p=0.45).<\/jats:p><jats:p>Conclusion: GVHD often presented with abdominal CT abnormalities. Diffuse small-bowel disease was associated with poor therapeutic response. CT may play a role in supporting clinical diagnosis of GI GVHD and determining prognosis.<\/jats:p>","DOI":"10.1259\/bjr\/60038597","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T18:39:51Z","timestamp":1328553591000},"page":"e416-e423","source":"Crossref","is-referenced-by-count":30,"title":["CT in the clinical and prognostic evaluation of acute graft-<i>vs<\/i>-host disease of the gastrointestinal tract"],"prefix":"10.1093","volume":"85","author":[{"given":"A","family":"Shimoni","sequence":"first","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Rimon","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hertz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Yerushalmi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Amitai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Portnoy","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Guranda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Nagler","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Apter","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"2024050213291334600_b1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0065-2776(08)60243-6","article-title":"Human marrow transplantation: an immunological perspective.","volume":"40","author":"Martin","year":"1987","journal-title":"Adv Immunol"},{"key":"2024050213291334600_b2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/00007890-198804000-00010","article-title":"Probability of finding HLA-matched unrelated marrow donors.","volume":"45","author":"Beatty","year":"1988","journal-title":"Transplantation"},{"key":"2024050213291334600_b3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1056\/NEJM199403243301206","article-title":"Bone marrow transplantation.","volume":"330","author":"Armitage","year":"1994","journal-title":"N Engl J Med"},{"key":"2024050213291334600_b4","first-page":"95","article-title":"Bone marrow transplantation: a review.","volume":"36","author":"Thomas","year":"1999","journal-title":"Semin Hematol"},{"key":"2024050213291334600_b5","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1001\/archinte.162.14.1558","article-title":"Allogeneic hematopoietic stem cell transplantation. 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