{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:16:07Z","timestamp":1791425767479,"version":"4.3.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1019","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the feasibility of depicting fibre architecture of human uteri in vivo using 3 T MR diffusion tensor imaging (MR-DTI) with a three-dimensional (3D) tractography approach. Quantitative results were provided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In vivo 3 T MR-DTI was performed on 30 volunteers (9 Caesarean delivery). Main diffusion directions reflecting the fibre orientation were determined using sensitivity-encoding single-shot echo planar imaging with diffusion-sensitised gradients (b=600 mm2 s\u22121) along 32 directions. A deterministic fibre-tracking algorithm was used to show in vivo fibre architecture, compared with ex vivo histological slides of cadaveric uteri. The number of fibres, the fibre density, the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were measured in 13 volunteers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Anisotropy was found in most regions of normal uteri and the preferential order of uterine fibres depicted, consisting of two representative fibre directions: circular and longitudinal, as in ex vivo studies. Two-thirds of uteri with a Caesarean scar did not have the same orientation of fibres in the anterior isthmus when compared with non-scarred myometrium. Quantitative data were obtained from 13 volunteers: Caesarean-scarred uteri (n=5) showed lower fibre number and density in the scarred anterior isthmus than the nulliparous uteri (n=8). No significant differences were found in FA (0.42\u00b10.02, 0.41\u00b10.02; p=0.25) and ADC (1.82\u00b10.18\u00d710\u22123 mm2 s\u22121, 1.93\u00b10.25\u00d710\u22123 mm2 s\u22121; p=0.20).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Fibre architecture of the human uterus can be depicted in vivo using 3 T MR-DTI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>3 T MR-DTI can help to provide an in vivo insight of uterine anatomy non-invasively, especially in females with previous Caesarean surgery, in order to provide better management of subsequent deliveries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr\/76693739","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T04:55:19Z","timestamp":1340859319000},"page":"e1009-e1017","source":"Crossref","is-referenced-by-count":34,"title":["<i>In vivo<\/i> 3 T MR diffusion tensor imaging for detection of the fibre architecture of the human uterus: a feasibility and quantitative study"],"prefix":"10.1093","volume":"85","author":[{"given":"F","family":"Fiocchi","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Nocetti","sequence":"additional","affiliation":[{"name":"Department of Physics, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Siopis","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Curr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Costi","sequence":"additional","affiliation":[{"name":"Department of Physics, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ligabue","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Torricelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Policlinico Hospital, University of Modena and Reggio-Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"2024050213263598600_b1","first-page":"461","article-title":"Arrangement of smooth muscle in the human uterus. 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