{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:43:02Z","timestamp":1790185382565,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1071","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To establish the interobserver reproducibility of tumour volumetry on individual multiparametric (mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>41 males with prostate cancer treated with prostatectomy (Cohort 1) or radical radiotherapy (Cohort 2), who had pre-treatment mpMRI [T \u00a02 weighted (T2W) MRI, diffusion-weighted (DW)-MRI and dynamic contrast-enhanced (DCE)-MRI], were studied retrospectively. Dominant intraprostatic lesions (DIPLs) were manually delineated on each sequence and volumes were compared between observers (n\u2009=\u200940 analyzable) and with radical prostatectomy (n\u2009=\u200920). Volume ratios of DW-MRI and DCE-MRI to T2W MRI were documented and compared between Gleason grade 3\u2009+\u20093, 3\u2009+\u20094 and 4\u2009+\u20093 or greater categories.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Limits of agreement of DIPL volumes between observers were: T2W MRI 0.9, \u22121.1\u2009cm3, DW-MRI 1.3, \u22121.7\u2009cm3 and DCE-MRI 0.74, \u22120.89\u2009cm3. In Cohort 1, T2W volumes overestimated fixed specimen histological volumes (+33% Observer 1, +16% Observer 2); DW- and DCE-MRI underestimated histological volume, the latter markedly so (\u221232% Observer 1, \u221279% Observer 2). Differences between T2W, DW- and DCE-MRI volumes were significant (p\u2009&amp;lt;\u200910\u22128). The ratio of DW-MRI volume (73.9\u2009\u00b1\u200918.1% Observer 1, 72.5\u2009\u00b1\u200921.9% Observer 2) and DCE-MRI volume (42.6\u2009\u00b1\u200924.6% Observer 1, 34.3\u2009\u00b1\u200924.9% Observer 2) to T2W volume was significantly different (p\u2009&amp;lt;\u200910\u22128), but these volume ratios did not differ between the Gleason grades.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The low variability of the DIPL volume on T2W MRI between Observers and agreement with histology indicates its suitability for delineation of gross tumour volume for radiotherapy planning. The volume of cellular tumour represented by DW-MRI is greater than the vascular (DCE) abnormality; ratios of both to T2W volume are independent of Gleason score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>(1) Manual volume measurement of tumour is reproducible within 1\u2009cm3 between observers on all sequences, confirming suitability across observers for radiotherapy planning. (2) Volumes derived on T2W MRI most accurately represent in vivo lesion volumes. (3) The proportion of cellular (DW-MRI) or vascular (DCE-MRI) volume to morphological (T2W MRI) volume is not affected by Gleason score.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20160416","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T17:22:18Z","timestamp":1483636938000},"source":"Crossref","is-referenced-by-count":19,"title":["Volumetry of the dominant intraprostatic tumour lesion: intersequence and interobserver differences on multiparametric MRI"],"prefix":"10.1093","volume":"90","author":[{"given":"Hugh","family":"Harvey","sequence":"first","affiliation":[{"name":"Cancer Research UK Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Orton","sequence":"additional","affiliation":[{"name":"Cancer Research UK Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica A","family":"Morgan","sequence":"additional","affiliation":[{"name":"Cancer Research UK Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Parker","sequence":"additional","affiliation":[{"name":"Academic Urology Unit, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dearnaley","sequence":"additional","affiliation":[{"name":"Academic Urology Unit, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita M","family":"deSouza","sequence":"additional","affiliation":[{"name":"Cancer Research UK Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"2024050213541113100_b1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0360-3016(98)00351-4","article-title":"Definition of the prostate in CT and MRI: a multi-observer study","volume":"43","author":"Rasch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024050213541113100_b2","first-page":"256","article-title":"Changes in target volumes definition by using MRI for prostate bed radiotherapy planning\u2014preliminary results. [In Czech.]","volume":"23","author":"Sefrova","year":"2010","journal-title":"Klin Onkol"},{"key":"2024050213541113100_b3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0167-8140(02)00407-3","article-title":"Magnetic resonance imaging in the radiation treatment planning of localized prostate cancer using intra-prostatic fiducial markers for computed tomography co-registration","volume":"66","author":"Parker","year":"2003","journal-title":"Radiother Oncol"},{"key":"2024050213541113100_b4","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.ijrobp.2011.02.050","article-title":"Prostate contouring variation: can it be fixed?","volume":"82","author":"Khoo","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024050213541113100_b5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ijrobp.2010.11.004","article-title":"Magnetic resonance imaging in postprostatectomy radiotherapy 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on pre-operative MRI: volumetric and dosimetric comparison to the RTOG guidelines","volume":"9","author":"Croke","year":"2014","journal-title":"Radiat Oncol"},{"key":"2024050213541113100_b9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1748-717X-8-126","article-title":"Variability in prostate and seminal vesicle delineations defined on magnetic resonance images, a multi-observer, -center and -sequence study","volume":"8","author":"Nyholm","year":"2013","journal-title":"Radiat Oncol"},{"key":"2024050213541113100_b10","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.acra.2014.12.022","article-title":"The role of pathology correlation approach in prostate cancer index lesion detection and quantitative analysis with multiparametric MRI","volume":"22","author":"Fedorov","year":"2015","journal-title":"Acad Radiol"},{"key":"2024050213541113100_b11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/0284186X.2013.837581","article-title":"Accurate prostate tumour detection with multiparametric magnetic resonance imaging: dependence on histological properties","volume":"53","author":"Borren","year":"2014","journal-title":"Acta Oncol"},{"key":"2024050213541113100_b12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.juro.2015.02.080","article-title":"Image guided focal therapy for magnetic resonance imaging visible prostate cancer: defining a 3-dimensional treatment margin based on magnetic resonance imaging histology co-registration analysis","volume":"194","author":"Le Nobin","year":"2015","journal-title":"J Urol"},{"key":"2024050213541113100_b13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/21681805.2014.907338","article-title":"How good is post-biopsy multiparametric magnetic resonance imaging in detecting and characterising the index lesion of localised prostate cancer?","volume":"48","author":"Engelhard","year":"2014","journal-title":"Scand J 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